Journal article Open Access

Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis

Makun, B.; Ebbo, A. A.

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    <subfield code="a">Keywords: Plant extract, Diospyros mespiliformis, toxicity study, phytochemical analysis</subfield>
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    <subfield code="u">Department of Veterinary Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto, Nigeria.</subfield>
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    <subfield code="p">Direct Research Journal of Biology and Biotechnology</subfield>
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    <subfield code="u">Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Sokoto State, Nigeria.</subfield>
    <subfield code="a">Makun, B.</subfield>
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    <subfield code="a">Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis</subfield>
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    <subfield code="a">&lt;p&gt;The study aimed to determine the toxicity level of aqueous leaf extract of &lt;em&gt;Diospyros mespiliformis&lt;/em&gt; on&amp;nbsp; Wister albino rats and the phytochemical and proximate composition of &lt;em&gt;Diospyros mespiliformis&lt;/em&gt;. The plant extract was found to contain Tannin, Saponin, flavonoid, glycoside, volatile fatty acid and Resin as constituent following phytochemical analysis.&amp;nbsp; On further study using proximate analysis shown that the following constituents&amp;nbsp;were found moisture (1%), Ash (7%), lipid (1.5%), fibre (2.5%), Nitrogen (1.89%), crude protein (11.81% and Carbohydrate (74.3%).&amp;nbsp; Sub-chronic toxicity studies of aqueous leaf extract of &lt;em&gt;Diospyros mespiliformis&lt;/em&gt; was conducted following 28 days administration of 1000, 2000 and 3000mg/kg to three group rats respectively, while the fourth group served as a control. Change in body weight, haematological and serum biochemical parameters as well as gross post changes used as indices of toxicity. The percentage yield of the extract was 16.0%. These were inappetence and weight loss in the first week of the study in the experimental groups but were no significant changes in body weight, haematology and serum biochemistry (P&amp;gt;0.05). It can&amp;nbsp;therefore&amp;nbsp;be inferred that this extract is safe at a dose of 3000mg/kg in rats following consecutive daily administration for 28 days.&lt;/p&gt;</subfield>
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