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Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis

Makun, B.; Ebbo, A. A.


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    "description": "<p>The study aimed to determine the toxicity level of aqueous leaf extract of <em>Diospyros mespiliformis</em> on&nbsp; Wister albino rats and the phytochemical and proximate composition of <em>Diospyros mespiliformis</em>. The plant extract was found to contain Tannin, Saponin, flavonoid, glycoside, volatile fatty acid and Resin as constituent following phytochemical analysis.&nbsp; On further study using proximate analysis shown that the following constituents&nbsp;were found moisture (1%), Ash (7%), lipid (1.5%), fibre (2.5%), Nitrogen (1.89%), crude protein (11.81% and Carbohydrate (74.3%).&nbsp; Sub-chronic toxicity studies of aqueous leaf extract of <em>Diospyros mespiliformis</em> was conducted following 28 days administration of 1000, 2000 and 3000mg/kg to three group rats respectively, while the fourth group served as a control. Change in body weight, haematological and serum biochemical parameters as well as gross post changes used as indices of toxicity. The percentage yield of the extract was 16.0%. These were inappetence and weight loss in the first week of the study in the experimental groups but were no significant changes in body weight, haematology and serum biochemistry (P&gt;0.05). It can&nbsp;therefore&nbsp;be inferred that this extract is safe at a dose of 3000mg/kg in rats following consecutive daily administration for 28 days.</p>", 
    "language": "ang", 
    "title": "Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis", 
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    "journal": {
      "volume": "3", 
      "issue": "5", 
      "pages": "103-109", 
      "title": "Direct Research Journal of Biology and Biotechnology"
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    "keywords": [
      "Keywords: Plant extract, Diospyros mespiliformis, toxicity study, phytochemical analysis"
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    "publication_date": "2019-08-24", 
    "creators": [
      {
        "affiliation": "Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Sokoto State, Nigeria.", 
        "name": "Makun, B."
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      {
        "affiliation": "Department of Veterinary Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto, Nigeria.", 
        "name": "Ebbo, A. A."
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