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Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis

Makun, B.; Ebbo, A. A.

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  <identifier identifierType="DOI">10.5281/zenodo.3376585</identifier>
      <creatorName>Makun, B.</creatorName>
      <affiliation>Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Sokoto State, Nigeria.</affiliation>
      <creatorName>Ebbo, A. A.</creatorName>
      <givenName>A. A.</givenName>
      <affiliation>Department of Veterinary Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto, Nigeria.</affiliation>
    <title>Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis</title>
    <subject>Keywords: Plant extract, Diospyros mespiliformis, toxicity study, phytochemical analysis</subject>
    <date dateType="Issued">2019-08-24</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3376584</relatedIdentifier>
    <rights rightsURI="">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">&lt;p&gt;The study aimed to determine the toxicity level of aqueous leaf extract of &lt;em&gt;Diospyros mespiliformis&lt;/em&gt; on&amp;nbsp; Wister albino rats and the phytochemical and proximate composition of &lt;em&gt;Diospyros mespiliformis&lt;/em&gt;. The plant extract was found to contain Tannin, Saponin, flavonoid, glycoside, volatile fatty acid and Resin as constituent following phytochemical analysis.&amp;nbsp; On further study using proximate analysis shown that the following constituents&amp;nbsp;were found moisture (1%), Ash (7%), lipid (1.5%), fibre (2.5%), Nitrogen (1.89%), crude protein (11.81% and Carbohydrate (74.3%).&amp;nbsp; Sub-chronic toxicity studies of aqueous leaf extract of &lt;em&gt;Diospyros mespiliformis&lt;/em&gt; was conducted following 28 days administration of 1000, 2000 and 3000mg/kg to three group rats respectively, while the fourth group served as a control. Change in body weight, haematological and serum biochemical parameters as well as gross post changes used as indices of toxicity. The percentage yield of the extract was 16.0%. These were inappetence and weight loss in the first week of the study in the experimental groups but were no significant changes in body weight, haematology and serum biochemistry (P&amp;gt;0.05). It can&amp;nbsp;therefore&amp;nbsp;be inferred that this extract is safe at a dose of 3000mg/kg in rats following consecutive daily administration for 28 days.&lt;/p&gt;</description>
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