Journal article Open Access

Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis

Makun, B.; Ebbo, A. A.


Citation Style Language JSON Export

{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.3376585", 
  "container_title": "Direct Research Journal of Biology and Biotechnology", 
  "language": "ang", 
  "title": "Prolonged (28 days) toxicity study, phytochemical and proximate composition of the aqueous leaf extract of Diosphyros mesipiliformis", 
  "issued": {
    "date-parts": [
      [
        2019, 
        8, 
        24
      ]
    ]
  }, 
  "abstract": "<p>The study aimed to determine the toxicity level of aqueous leaf extract of <em>Diospyros mespiliformis</em> on&nbsp; Wister albino rats and the phytochemical and proximate composition of <em>Diospyros mespiliformis</em>. The plant extract was found to contain Tannin, Saponin, flavonoid, glycoside, volatile fatty acid and Resin as constituent following phytochemical analysis.&nbsp; On further study using proximate analysis shown that the following constituents&nbsp;were found moisture (1%), Ash (7%), lipid (1.5%), fibre (2.5%), Nitrogen (1.89%), crude protein (11.81% and Carbohydrate (74.3%).&nbsp; Sub-chronic toxicity studies of aqueous leaf extract of <em>Diospyros mespiliformis</em> was conducted following 28 days administration of 1000, 2000 and 3000mg/kg to three group rats respectively, while the fourth group served as a control. Change in body weight, haematological and serum biochemical parameters as well as gross post changes used as indices of toxicity. The percentage yield of the extract was 16.0%. These were inappetence and weight loss in the first week of the study in the experimental groups but were no significant changes in body weight, haematology and serum biochemistry (P&gt;0.05). It can&nbsp;therefore&nbsp;be inferred that this extract is safe at a dose of 3000mg/kg in rats following consecutive daily administration for 28 days.</p>", 
  "author": [
    {
      "family": "Makun, B."
    }, 
    {
      "family": "Ebbo, A. A."
    }
  ], 
  "page": "103-109", 
  "volume": "3", 
  "type": "article-journal", 
  "issue": "5", 
  "id": "3376585"
}
1
6
views
downloads
All versions This version
Views 11
Downloads 66
Data volume 1.0 MB1.0 MB
Unique views 11
Unique downloads 44

Share

Cite as