Journal article Open Access

CO-CRYSTALLIZATION: A NOVEL APPROACH TO ENHANCE THE DISSOLUTION OF POORLY SOLUBLE DRUGS

S. J. Shankar1*, Jaswanth Gowda B. H.1, Akshatha R. S.2, Basavaraj Metikurki1


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  <identifier identifierType="DOI">10.5281/zenodo.3362134</identifier>
  <creators>
    <creator>
      <creatorName>S. J. Shankar1*, Jaswanth Gowda B. H.1, Akshatha R. S.2, Basavaraj Metikurki1</creatorName>
      <affiliation>1Vivekananda College of Pharmacy, Dr. Rajkumar Road, Rajajinagar 2nd Stage, Bengaluru – 560 055. 2PES College of Pharmacy, 50 feet Road, Hanumanth nagar, Srinagara, Bengaluru – 560 050.</affiliation>
    </creator>
  </creators>
  <titles>
    <title>CO-CRYSTALLIZATION: A NOVEL APPROACH TO ENHANCE THE DISSOLUTION OF POORLY SOLUBLE DRUGS</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2019</publicationYear>
  <subjects>
    <subject>Co-Crystals, Dissolution Rate Enhancement, Supramolecular Synthon, Non Ionic Bond, Method Of Preparation.</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2019-08-07</date>
  </dates>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3362134</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3362133</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/iajpr</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Approximately 40% of newly synthesized drugs are not able to enter market due to biopharmaceutical issues like poor solubility and poor permeability. Most number of drugs marketed is administered orally hence solubility enhancement plays a major role. There are different techniques to upgrade the dissolvability of inefficiently soluble drugs including pro-drug approach, salt formation, particle size reduction, complexation and solid dispersion. Out of all other techniques, salt formation is one of majorly used technique to improve physicochemical characteristics of drugs which includes formation of ionic bond. But nowadays development of co-crystals has evolved as a suitable technique towards improving the dissolvability and bioavailability of ineffectively soluble drugs that includes non-ionic bond formation. In this paper a brief and accurate precis of pharmaceutical co-crystals is stated with specific spotlight on co-crystal preparation methodologies, mechanism of co-crystal formation, characterization methods and some of the examples of pharmaceutical co-crystals are additionally outlined. The difference between salts and co-crystals, regulatory facet and also the future prospective of co-crystallization is being discussed.&lt;/p&gt;</description>
  </descriptions>
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