10.5281/zenodo.3357045
https://zenodo.org/records/3357045
oai:zenodo.org:3357045
Yirga Kassa
Yirga Kassa
Department of Chemistry, College of Natural Sciences, Jimma University, Jimma, Ethiopia, P.O.Box 378
Tsegaye Deyou
Tsegaye Deyou
Department of Chemistry, College of Natural Sciences, Salale University, Fiche, Ethiopia, P.O.Box 245
Dele Abdissa
Dele Abdissa
Department of Chemistry, College of Natural Sciences, Jimma University, Jimma, Ethiopia, P.O.Box 378
Antimicrobial Activities of Tetracyclic Triterpenoids from the Seeds of Azadirachata indica
Zenodo
2019
Azadirachata indica
Aspergillus flavus
Azadiradione
Epoxyazadiradione
2019-07-31
10.5281/zenodo.3357044
Creative Commons Attribution 4.0 International
Two known tetracyclic triterpenoids were isolated from the seeds of Azadirachta indica to evaluate for antimicrobial activities. In this regard, the powdered seeds of Azadirachta indica were extracted using chloroform/methanol (1:1) to provide 60 g of oily crude extract after the removal of the solvent using a rotary evaporator at 50°C. The crude extract was subjected to column chromatographic separation to afford two known compounds identified as azadiradione (1) and epoxyazadiradione (2). The crude extract and isolated compounds were evaluated against four bacterial and two fungal strains. Accordingly, the crude extract was found to be active against P. aeruginosa (11 mm) and E. coli (15 mm). Whereas, compound 1 showed significant activity against S.aureus (18 mm) and P. aeruginosa (15 mm).