# WARNING: this file is not sorted! # db id alt E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests neg_sites_in_bin neg_sites neg_adj_pvalue log_neg_adj_pvalue fisher_adj_pvalue log_fisher_adj_pvalue 1 MA0090.2 TEAD1 7.7e-022 1.5e-024 -54.87 0.0 135 491 196 359 0.27495 6.1e-027 245 32 153 1.0e0000 0.00 4.3e-010 -21.56 1 MA0139.1 CTCF 2.4e0000 4.6e-003 -5.39 0.0 144 482 73 160 0.29876 1.9e-005 240 13 52 1.0e0000 0.00 7.6e-001 -0.27 1 MA0599.1 KLF5 5.5e0000 1.1e-002 -4.55 0.0 453 491 296 303 0.92261 4.3e-005 245 92 99 1.0e0000 0.00 1.0e0000 -0.00 1 MA0808.1 TEAD3 2.2e-036 4.2e-039 -88.37 0.0 135 493 194 299 0.27383 1.7e-041 246 24 97 1.0e0000 0.00 8.5e-010 -20.88 1 MA0809.1 TEAD4 3.5e-025 6.7e-028 -62.57 0.0 135 491 200 353 0.27495 2.7e-030 245 32 152 1.0e0000 0.00 1.1e-011 -25.23 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # E-value: The expected number motifs that would have least one # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization). # neg_sites_in_bin: The number of negative sequences where the best # match to the motif falls in the reported region. # This value is rounded but the underlying value may contain # fractional counts. # Note: This number may be less than the number of negative have a # best match in the region. # The reason for this is that a sequence may have many matches that # score equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # neg_sites: The number of negative sequences containing a match to the # motif above the minimum score threshold. # When score optimization is enabled the score threshold may be raised # higher than the minimum. # neg_adj_pvalue: The probability that any tested region in the negative # sequences would be as enriched for best matches to this motif # according to the Binomial test. # log_neg_adj_pvalue: Log of negative adjusted p-value. # fisher_adj_pvalue: Fisher adjusted p-value before it gets adjusted to the # number of motifs in the input database(s). # Refers to the E-value definition using the discriminative mode. # log_fisher_adj_pvalue: Log of Fisher adjusted p-value.