# WARNING: this file is not sorted! # db id alt E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 MA0002.2 RUNX1 1.6e-002 3.0e-005 -10.41 0.0 192 490 266 527 0.39184 1.2e-007 244 1 MA0028.2 ELK1 2.3e-002 4.4e-005 -10.02 0.0 219 491 133 213 0.44603 1.8e-007 245 1 MA0029.1 Mecom 5.5e-016 1.1e-018 -41.38 0.0 109 487 84 142 0.22382 4.4e-021 243 1 MA0035.3 Gata1 4.8e-095 9.2e-098 -223.43 0.0 84 490 267 418 0.17143 3.8e-100 244 1 MA0036.2 GATA2 1.3e-119 2.6e-122 -279.98 0.0 113 487 339 442 0.23203 1.1e-124 243 1 MA0037.2 GATA3 1.3e-045 2.5e-048 -109.61 0.0 101 493 140 200 0.20487 1.0e-050 246 1 MA0048.2 NHLH1 7.4e-002 1.4e-004 -8.86 0.0 155 491 148 333 0.31568 5.8e-007 245 1 MA0062.2 Gabpa 3.1e-002 6.0e-005 -9.72 0.0 220 490 202 345 0.44898 2.5e-007 244 1 MA0076.2 ELK4 1.8e-003 3.4e-006 -12.59 0.0 218 490 222 376 0.44490 1.4e-008 244 1 MA0098.3 ETS1 6.9e-003 1.3e-005 -11.23 0.0 243 491 258 411 0.49491 5.4e-008 245 1 MA0099.2 FOS::JUN 1.4e0000 2.7e-003 -5.90 0.0 80 494 123 522 0.16194 1.1e-005 246 1 MA0136.2 ELF5 1.1e0000 2.2e-003 -6.13 0.0 294 490 350 505 0.60000 9.0e-006 244 1 MA0140.2 GATA1::TAL1 9.4e-028 1.8e-030 -68.49 0.0 97 483 139 259 0.20083 7.5e-033 241 1 MA0156.2 FEV 3.3e-003 6.4e-006 -11.96 0.0 235 491 256 417 0.47862 2.6e-008 245 1 MA0462.1 BATF::JUN 1.0e-001 2.0e-004 -8.52 0.0 162 490 131 278 0.33061 8.1e-007 244 1 MA0473.2 ELF1 1.3e-001 2.5e-004 -8.28 0.0 213 489 108 175 0.43558 1.0e-006 244 1 MA0474.2 ERG 5.8e-005 1.1e-007 -16.00 0.0 219 491 253 424 0.44603 4.6e-010 245 1 MA0475.2 FLI1 1.5e-004 2.9e-007 -15.05 0.0 219 491 207 339 0.44603 1.2e-009 245 1 MA0476.1 FOS 2.1e-003 4.1e-006 -12.40 0.0 174 490 117 216 0.35510 1.7e-008 244 1 MA0477.1 FOSL1 1.4e-006 2.6e-009 -19.75 0.0 174 490 111 185 0.35510 1.1e-011 244 1 MA0478.1 FOSL2 6.2e-004 1.2e-006 -13.64 0.0 166 490 129 248 0.33878 4.9e-009 244 1 MA0482.1 Gata4 1.6e-091 3.0e-094 -215.33 0.0 102 490 285 417 0.20816 1.2e-096 244 1 MA0489.1 JUN(var.2) 4.9e-001 9.5e-004 -6.96 0.0 171 487 124 253 0.35113 3.9e-006 243 1 MA0490.1 JUNB 1.6e-004 3.1e-007 -14.99 0.0 174 490 112 198 0.35510 1.3e-009 244 1 MA0491.1 JUND 6.2e-005 1.2e-007 -15.94 0.0 172 490 89 148 0.35102 4.9e-010 244 1 MA0492.1 JUND(var.2) 6.3e-001 1.2e-003 -6.71 0.0 144 486 71 151 0.29630 5.0e-006 242 1 MA0499.1 Myod1 6.6e0000 1.3e-002 -4.36 0.0 164 488 129 288 0.33607 5.3e-005 243 1 MA0500.1 Myog 8.0e-001 1.5e-003 -6.48 0.0 160 490 113 244 0.32653 6.3e-006 244 1 MA0501.1 MAF::NFE2 5.0e0000 9.6e-003 -4.64 0.0 54 486 41 194 0.11111 4.0e-005 242 1 MA0511.2 RUNX2 1.8e-003 3.5e-006 -12.58 0.0 210 492 245 437 0.42683 1.4e-008 245 1 MA0521.1 Tcf12 3.5e-001 6.8e-004 -7.29 0.0 160 490 123 266 0.32653 2.8e-006 244 1 MA0522.2 TCF3 3.6e0000 7.0e-003 -4.97 0.0 155 491 161 389 0.31568 2.8e-005 245 1 MA0591.1 Bach1::Mafk 7.4e0000 1.4e-002 -4.26 0.0 74 486 40 142 0.15226 5.9e-005 242 1 MA0595.1 SREBF1 6.9e-002 1.3e-004 -8.92 0.0 45 491 41 197 0.09165 5.5e-007 245 1 MA0596.1 SREBF2 3.3e-001 6.3e-004 -7.37 0.0 45 491 45 238 0.09165 2.6e-006 245 1 MA0598.2 EHF 2.1e-002 4.1e-005 -10.10 0.0 273 489 206 292 0.55828 1.7e-007 244 1 MA0640.1 ELF3 4.7e-001 9.2e-004 -7.00 0.0 286 488 122 161 0.58607 3.8e-006 243 1 MA0641.1 ELF4 2.7e0000 5.3e-003 -5.24 0.0 183 489 98 187 0.37423 2.2e-005 244 1 MA0645.1 ETV6 4.1e-001 8.0e-004 -7.13 0.0 181 491 209 440 0.36864 3.3e-006 245 1 MA0655.1 JDP2 1.0e-003 2.0e-006 -13.14 0.0 174 492 100 177 0.35366 8.1e-009 245 1 MA0684.1 RUNX3 9.4e-005 1.8e-007 -15.53 0.0 129 491 181 460 0.26273 7.4e-010 245 1 MA0686.1 SPDEF 1.3e-001 2.6e-004 -8.26 0.0 218 490 116 187 0.44490 1.1e-006 244 1 MA0742.1 Klf12 4.1e0000 7.9e-003 -4.84 0.0 202 486 99 174 0.41564 3.3e-005 242 1 MA0759.1 ELK3 1.7e-001 3.3e-004 -8.01 0.0 235 491 235 393 0.47862 1.4e-006 245 1 MA0760.1 ERF 1.7e-004 3.3e-007 -14.92 0.0 353 491 317 372 0.71894 1.4e-009 245 1 MA0761.1 ETV1 1.9e-001 3.6e-004 -7.92 0.0 219 491 248 445 0.44603 1.5e-006 245 1 MA0762.1 ETV2 1.6e-004 3.1e-007 -14.98 0.0 236 490 182 275 0.48163 1.3e-009 244 1 MA0763.1 ETV3 1.1e-001 2.1e-004 -8.45 0.0 225 491 246 428 0.45825 8.7e-007 245 1 MA0764.1 ETV4 7.1e-002 1.4e-004 -8.90 0.0 231 491 268 458 0.47047 5.6e-007 245 1 MA0765.1 ETV5 1.6e-003 3.0e-006 -12.71 0.0 219 491 274 476 0.44603 1.2e-008 245 1 MA0766.1 GATA5 3.0e-145 5.8e-148 -339.02 0.0 85 493 368 539 0.17241 2.4e-150 246 1 MA0799.1 RFX4 4.0e0000 7.8e-003 -4.86 0.0 11 485 13 146 0.02268 3.2e-005 242 1 MA0816.1 Ascl2 4.3e0000 8.2e-003 -4.80 0.0 157 491 170 410 0.31976 3.4e-005 245 1 MA0830.1 TCF4 3.6e0000 7.0e-003 -4.96 0.0 155 491 159 384 0.31568 2.9e-005 245 1 MA0833.1 ATF4 2.1e0000 4.1e-003 -5.49 0.0 144 488 59 124 0.29508 1.7e-005 243 1 MA0841.1 NFE2 6.1e-001 1.2e-003 -6.75 0.0 88 490 28 67 0.17959 4.8e-006 244 1 MA0871.1 TFEC 5.9e0000 1.1e-002 -4.47 0.0 55 491 81 466 0.11202 4.7e-005 245 1 MA0884.1 DUXA 2.2e-005 4.3e-008 -16.97 0.0 52 488 73 313 0.10656 1.8e-010 243 1 MA0891.1 GSC2 1.0e0000 2.0e-003 -6.22 0.0 53 491 87 500 0.10794 8.2e-006 245 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # E-value: The expected number motifs that would have least one # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).