# WARNING: this file is not sorted! # db id alt E-value adj_p-value log_adj_p-value bin_location bin_width total_width sites_in_bin total_sites p_success p-value mult_tests 1 MA0018.2 CREB1 5.5e-010 1.1e-012 -27.58 0.0 73 493 429 2012 0.14807 4.3e-015 246 1 MA0019.1 Ddit3::Cebpa 1.8e-281 3.4e-284 -652.71 0.0 69 489 1004 2151 0.14110 1.4e-286 244 1 MA0025.1 NFIL3 1.2e-099 2.4e-102 -233.99 0.0 50 490 369 1046 0.10204 9.9e-105 244 1 MA0027.2 EN1 2.1e-006 4.1e-009 -19.32 0.0 39 493 255 2110 0.07911 1.6e-011 246 1 MA0028.2 ELK1 2.5e-003 4.9e-006 -12.23 0.0 157 491 248 577 0.31976 2.0e-008 245 1 MA0038.1 Gfi1 8.5e-007 1.6e-009 -20.23 0.0 37 491 275 2402 0.07536 6.7e-012 245 1 MA0043.2 HLF 2.3e-410 4.5e-413 -949.47 0.0 73 489 1100 1868 0.14928 1.8e-415 244 1 MA0062.2 Gabpa 4.8e-002 9.2e-005 -9.29 0.0 144 490 448 1247 0.29388 3.8e-007 244 1 MA0067.1 Pax2 4.5e-011 8.7e-014 -30.07 0.0 197 493 1206 2516 0.39959 3.6e-016 246 1 MA0075.2 Prrx2 4.3e-002 8.3e-005 -9.39 0.0 21 493 155 2391 0.04260 3.4e-007 246 1 MA0076.2 ELK4 7.0e-003 1.3e-005 -11.22 0.0 144 490 510 1418 0.29388 5.5e-008 244 1 MA0089.1 MAFG::NFE2L1 1.7e-037 3.2e-040 -90.93 0.0 103 495 823 2536 0.20808 1.3e-042 247 1 MA0090.2 TEAD1 4.6e-002 8.8e-005 -9.34 0.0 171 491 968 2440 0.34827 3.6e-007 245 1 MA0098.3 ETS1 9.1e-008 1.7e-010 -22.47 0.0 145 491 624 1656 0.29532 7.1e-013 245 1 MA0099.2 FOS::JUN 9.4e-094 1.8e-096 -220.45 0.0 146 494 1252 2524 0.29555 7.4e-099 246 1 MA0100.2 Myb 3.1e-004 6.0e-007 -14.32 0.0 93 491 345 1354 0.18941 2.5e-009 245 1 MA0102.3 CEBPA 1.8e-528 3.5e-531 -1221.41 0.0 74 490 1261 1958 0.15102 1.4e-533 244 1 MA0117.2 Mafb 1.1e-023 2.2e-026 -59.10 0.0 83 489 578 2184 0.16973 8.9e-029 244 1 MA0119.1 NFIC::TLX1 2.5e0000 4.8e-003 -5.35 0.0 169 487 127 270 0.34702 2.0e-005 243 1 MA0136.2 ELF5 1.1e0000 2.2e-003 -6.13 0.0 180 490 959 2334 0.36735 8.9e-006 244 1 MA0142.1 Pou5f1::Sox2 1.7e-003 3.2e-006 -12.65 0.0 42 486 231 1845 0.08642 1.3e-008 242 1 MA0150.2 Nfe2l2 8.8e-031 1.7e-033 -75.46 0.0 126 486 562 1351 0.25926 7.0e-036 242 1 MA0156.2 FEV 7.6e-008 1.5e-010 -22.64 0.0 145 491 633 1680 0.29532 6.0e-013 245 1 MA0161.1 NFIC 2.6e-001 5.0e-004 -7.61 0.0 153 495 892 2534 0.30909 2.0e-006 247 1 MA0461.2 Atoh1 5.0e0000 9.6e-003 -4.64 0.0 53 491 253 1836 0.10794 3.9e-005 245 1 MA0462.1 BATF::JUN 1.1e-052 2.2e-055 -125.87 0.0 186 490 903 1556 0.37959 8.9e-058 244 1 MA0466.2 CEBPB 8.6e-213 1.7e-215 -494.55 0.0 69 491 737 1551 0.14053 6.7e-218 245 1 MA0468.1 DUX4 8.2e-050 1.6e-052 -119.28 0.0 66 490 298 868 0.13469 6.5e-055 244 1 MA0473.2 ELF1 2.5e-001 4.7e-004 -7.66 0.0 137 489 200 536 0.28016 1.9e-006 244 1 MA0474.2 ERG 5.5e-005 1.1e-007 -16.06 0.0 145 491 633 1739 0.29532 4.3e-010 245 1 MA0475.2 FLI1 2.3e-009 4.4e-012 -26.15 0.0 153 491 510 1229 0.31161 1.8e-014 245 1 MA0476.1 FOS 4.0e-072 7.6e-075 -170.66 0.0 208 490 875 1283 0.42449 3.1e-077 244 1 MA0477.1 FOSL1 2.0e-081 3.9e-084 -192.06 0.0 212 490 807 1114 0.43265 1.6e-086 244 1 MA0478.1 FOSL2 4.1e-056 7.9e-059 -133.78 0.0 236 490 916 1293 0.48163 3.2e-061 244 1 MA0483.1 Gfi1b 6.5e-003 1.2e-005 -11.29 0.0 40 490 199 1660 0.08163 5.1e-008 244 1 MA0488.1 JUN 1.2e-628 2.3e-631 -1452.08 0.0 76 488 1288 1757 0.15574 9.6e-634 243 1 MA0489.1 JUN(var.2) 1.0e-069 1.9e-072 -165.13 0.0 197 487 935 1455 0.40452 7.9e-075 243 1 MA0490.1 JUNB 4.6e-078 8.8e-081 -184.33 0.0 212 490 844 1189 0.43265 3.6e-083 244 1 MA0491.1 JUND 1.0e-065 2.0e-068 -155.91 0.0 194 490 653 959 0.39592 8.0e-071 244 1 MA0492.1 JUND(var.2) 4.0e-295 7.6e-298 -684.14 0.0 88 486 807 1214 0.18107 3.2e-300 242 1 MA0494.1 Nr1h3::Rxra 1.7e0000 3.2e-003 -5.75 0.0 58 482 270 1748 0.12033 1.3e-005 240 1 MA0495.1 MAFF 4.7e-015 9.1e-018 -39.24 0.0 107 483 600 1925 0.22153 3.8e-020 241 1 MA0496.1 MAFK 3.2e-016 6.1e-019 -41.94 0.0 106 486 546 1727 0.21811 2.5e-021 242 1 MA0501.1 MAF::NFE2 2.8e-023 5.5e-026 -58.16 0.0 168 486 490 940 0.34568 2.3e-028 242 1 MA0591.1 Bach1::Mafk 3.0e-015 5.7e-018 -39.71 0.0 216 486 408 654 0.44444 2.4e-020 242 1 MA0595.1 SREBF1 1.5e-003 3.0e-006 -12.73 0.0 67 491 174 840 0.13646 1.2e-008 245 1 MA0596.1 SREBF2 8.1e-007 1.6e-009 -20.27 0.0 67 491 205 940 0.13646 6.4e-012 245 1 MA0598.2 EHF 7.9e-001 1.5e-003 -6.48 0.0 129 489 366 1133 0.26380 6.3e-006 244 1 MA0604.1 Atf1 1.5e-010 2.8e-013 -28.89 0.0 91 493 225 732 0.18458 1.2e-015 246 1 MA0605.1 Atf3 1.1e-047 2.2e-050 -114.36 0.0 123 493 706 1679 0.24949 8.8e-053 246 1 MA0610.1 DMRT3 8.0e-003 1.5e-005 -11.08 0.0 28 490 158 1777 0.05714 6.3e-008 244 1 MA0611.1 Dux 5.7e-009 1.1e-011 -25.24 0.0 65 493 222 1022 0.13185 4.4e-014 246 1 MA0615.1 Gmeb1 2.9e-001 5.6e-004 -7.48 0.0 102 484 231 830 0.21074 2.3e-006 241 1 MA0620.1 Mitf 5.2e0000 1.0e-002 -4.60 0.0 157 491 858 2398 0.31976 4.1e-005 245 1 MA0623.1 Neurog1 2.3e-001 4.3e-004 -7.74 0.0 35 491 238 2456 0.07128 1.8e-006 245 1 MA0627.1 Pou2f3 2.2e-001 4.2e-004 -7.78 0.0 49 485 160 1095 0.10103 1.7e-006 242 1 MA0629.1 Rhox11 5.6e-029 1.1e-031 -71.31 0.0 48 484 358 1852 0.09917 4.5e-034 241 1 MA0632.1 Tcfl5 2.9e-001 5.5e-004 -7.50 0.0 339 491 1035 1386 0.69043 2.2e-006 245 1 MA0634.1 ALX3 5.9e-002 1.1e-004 -9.08 0.0 21 491 150 2294 0.04277 4.7e-007 245 1 MA0639.1 DBP 4.8e-396 9.3e-399 -916.50 0.0 73 489 861 1257 0.14928 3.8e-401 244 1 MA0642.1 EN2 1.7e0000 3.4e-003 -5.70 0.0 39 491 243 2335 0.07943 1.4e-005 245 1 MA0645.1 ETV6 5.9e-002 1.1e-004 -9.08 0.0 181 491 773 1818 0.36864 4.6e-007 245 1 MA0655.1 JDP2 4.1e-061 7.9e-064 -145.30 0.0 166 492 641 1080 0.33740 3.2e-066 245 1 MA0656.1 JDP2(var.2) 1.8e-133 3.4e-136 -311.93 0.0 87 489 311 423 0.17791 1.4e-138 244 1 MA0659.1 MAFG 5.9e-004 1.1e-006 -13.69 0.0 110 480 282 901 0.22917 4.8e-009 239 1 MA0661.1 MEOX1 1.5e-001 2.9e-004 -8.13 0.0 41 491 233 2039 0.08350 1.2e-006 245 1 MA0666.1 MSX1 7.2e-007 1.4e-009 -20.40 0.0 37 493 263 2283 0.07505 5.6e-012 246 1 MA0671.1 NFIX 4.8e-002 9.3e-005 -9.29 0.0 152 492 893 2513 0.30894 3.8e-007 245 1 MA0681.1 Phox2b 4.9e-020 9.5e-023 -50.71 0.0 46 490 266 1467 0.09388 3.9e-025 244 1 MA0686.1 SPDEF 2.3e-001 4.4e-004 -7.73 0.0 124 490 224 671 0.25306 1.8e-006 244 1 MA0705.1 Lhx8 6.5e-003 1.2e-005 -11.29 0.0 21 493 127 1796 0.04260 5.1e-008 246 1 MA0706.1 MEOX2 1.5e-006 2.8e-009 -19.69 0.0 111 491 682 2391 0.22607 1.2e-011 245 1 MA0708.1 MSX2 3.3e-002 6.4e-005 -9.66 0.0 21 493 133 1969 0.04260 2.6e-007 246 1 MA0709.1 Msx3 1.1e-003 2.1e-006 -13.10 0.0 41 493 234 1938 0.08316 8.4e-009 246 1 MA0713.1 PHOX2A 2.1e-015 4.1e-018 -40.04 0.0 46 490 284 1722 0.09388 1.7e-020 244 1 MA0743.1 SCRT1 2.0e-001 3.9e-004 -7.86 0.0 8 486 20 343 0.01646 1.6e-006 242 1 MA0744.1 SCRT2 4.4e-007 8.5e-010 -20.89 0.0 52 488 80 334 0.10656 3.5e-012 243 1 MA0759.1 ELK3 4.8e-004 9.2e-007 -13.90 0.0 141 491 550 1549 0.28717 3.7e-009 245 1 MA0760.1 ERF 1.9e-004 3.7e-007 -14.81 0.0 141 491 509 1412 0.28717 1.5e-009 245 1 MA0761.1 ETV1 1.1e-003 2.0e-006 -13.10 0.0 155 491 685 1808 0.31568 8.4e-009 245 1 MA0762.1 ETV2 2.2e-005 4.1e-008 -17.00 0.0 142 490 369 959 0.28980 1.7e-010 244 1 MA0763.1 ETV3 1.5e-006 2.9e-009 -19.67 0.0 157 491 737 1874 0.31976 1.2e-011 245 1 MA0764.1 ETV4 3.5e-005 6.7e-008 -16.52 0.0 145 491 697 1928 0.29532 2.7e-010 245 1 MA0765.1 ETV5 8.9e-003 1.7e-005 -10.97 0.0 155 491 756 2037 0.31568 7.0e-008 245 1 MA0808.1 TEAD3 2.8e-005 5.3e-008 -16.75 0.0 159 493 699 1779 0.32252 2.2e-010 246 1 MA0809.1 TEAD4 9.6e-003 1.9e-005 -10.89 0.0 165 491 943 2435 0.33605 7.6e-008 245 1 MA0833.1 ATF4 1.4e-829 2.6e-832 -1914.79 0.0 74 488 1486 1869 0.15164 1.1e-834 243 1 MA0834.1 ATF7 1.0e-076 1.9e-079 -181.25 0.0 81 487 213 336 0.16632 8.0e-082 243 1 MA0835.1 BATF3 6.7e-012 1.3e-014 -31.98 0.0 75 487 45 80 0.15400 5.3e-017 243 1 MA0836.1 CEBPD 1.1e-302 2.1e-305 -701.55 0.0 73 491 861 1524 0.14868 8.6e-308 245 1 MA0837.1 CEBPE 1.5e-337 2.9e-340 -781.81 0.0 73 491 1051 1981 0.14868 1.2e-342 245 1 MA0838.1 CEBPG 1.0e-114 1.9e-117 -268.74 0.0 79 491 403 763 0.16090 7.9e-120 245 1 MA0840.1 Creb5 8.9e-177 1.7e-179 -411.62 0.0 73 489 395 583 0.14928 7.0e-182 244 1 MA0841.1 NFE2 3.3e-033 6.3e-036 -81.05 0.0 206 490 330 459 0.42041 2.6e-038 244 1 MA0842.1 NRL 9.9e-014 1.9e-016 -36.20 0.0 84 490 604 2508 0.17143 7.8e-019 244 1 MA0843.1 TEF 1.2e-151 2.4e-154 -353.74 0.0 69 489 452 854 0.14110 9.7e-157 244 1 MA0844.1 XBP1 1.2e0000 2.2e-003 -6.11 0.0 159 487 157 360 0.32649 9.1e-006 243 1 MA0861.1 TP73 3.6e0000 6.9e-003 -4.98 0.0 67 483 82 380 0.13872 2.9e-005 241 1 MA0862.1 GMEB2 1.4e-003 2.7e-006 -12.83 0.0 71 493 181 833 0.14402 1.1e-008 246 1 MA0871.1 TFEC 6.7e0000 1.3e-002 -4.34 0.0 133 491 617 1987 0.27088 5.3e-005 245 1 MA0876.1 BSX 3.0e0000 5.8e-003 -5.16 0.0 21 493 137 2235 0.04260 2.3e-005 246 1 MA0880.1 Dlx3 4.5e-007 8.7e-010 -20.86 0.0 39 493 285 2382 0.07911 3.6e-012 246 1 MA0881.1 Dlx4 4.0e-008 7.7e-011 -23.29 0.0 39 493 289 2371 0.07911 3.1e-013 246 1 MA0882.1 DLX6 3.3e-007 6.3e-010 -21.18 0.0 21 493 173 2315 0.04260 2.6e-012 246 1 MA0884.1 DUXA 2.6e-072 5.1e-075 -171.07 0.0 52 488 458 1706 0.10656 2.1e-077 243 1 MA0885.1 Dlx2 3.3e-005 6.4e-008 -16.57 0.0 41 493 273 2239 0.08316 2.6e-010 246 1 MA0896.1 Hmx1 1.2e0000 2.4e-003 -6.03 0.0 12 484 56 1207 0.02479 1.0e-005 241 1 MA0900.1 HOXA2 4.7e-002 9.0e-005 -9.32 0.0 41 491 270 2383 0.08350 3.7e-007 245 1 MA0912.1 Hoxd3 1.5e0000 2.8e-003 -5.86 0.0 27 485 141 1752 0.05567 1.2e-005 242 ## # Detailed descriptions of columns in this file: # # db: The name of the database (file name) that contains the motif. # id: A name for the motif that is unique in the motif database file. # alt: An alternate name of the motif that may be provided # in the motif database file. # E-value: The expected number motifs that would have least one # region as enriched for best matches to the motif as the reported region. # The E-value is the p-value multiplied by the number of motifs in the # input database(s). # adj_p-value: The probability that any tested region would be as enriched for # best matches to this motif as the reported region is. # By default the p-value is calculated by using the one-tailed binomial # test on the number of sequences with a match to the motif # that have their best match in the reported region, corrected for # the number of regions and score thresholds tested. # The test assumes that the probability that the best match in a sequence # falls in the region is the region width divided by the # number of places a motif # can align in the sequence (sequence length minus motif width plus 1). # When CentriMo is run in discriminative mode with a negative # set of sequences, the p-value of a region is calculated # using the Fisher exact test on the # enrichment of best matches in the positive sequences relative # to the negative sequences, corrected # for the number of regions and score thresholds tested. # The test assumes that the probability that the best match (if any) # falls into a given region # is the same for all positive and negative sequences. # log_adj_p-value: Log of adjusted p-value. # bin_location: Location of the center of the most enriched region. # bin_width: The width (in sequence positions) of the most enriched region. # A best match to the motif is counted as being in the region if the # center of the motif falls in the region. # total_width: The window maximal size which can be reached for this motif: # rounded(sequence length - motif length +1)/2 # sites_in_bin: The number of (positive) sequences whose best match to the motif # falls in the reported region. # Note: This number may be less than the number of # (positive) sequences that have a best match in the region. # The reason for this is that a sequence may have many matches that score # equally best. # If n matches have the best score in a sequence, 1/n is added to the # appropriate bin for each match. # total_sites: The number of sequences containing a match to the motif # above the score threshold. # p_success: The probability of falling in the enriched window: # bin width / total width # p-value: The uncorrected p-value before it gets adjusted to the # number of multiple tests to give the adjusted p-value. # mult_tests: This is the number of multiple tests (n) done for this motif. # It was used to correct the original p-value of a region for # multiple tests using the formula: # p' = 1 - (1-p)^n where p is the uncorrected p-value. # The number of multiple tests is the number of regions # considered times the number of score thresholds considered. # It depends on the motif length, sequence length, and the type of # optimizations being done (central enrichment, local enrichment, # score optimization).