Journal article Open Access

Effects of Finasteride on Prostate Gland Weight, Spermatogenesis and Fertility in Mice

Mohammad Oda Selman; Ula M. Al- Kawaz; Ahmed H. Shyaa; Azhar M. Suhail

Finasteride is a drug used in treatment men with benign prostatic hyperplasia (BPH), blocks the action of an enzyme called 5 alpha-reductase enzyme; an enzyme that converts testosterone to dihydrotestosterone (DHT). DHT plays an important role to cause benign prostatic hyperplasia (BPH), so this action will increase testosterone levels in the body, which decreases prostate size, therefore the finasteride used for BPH treatment.  To evaluate effects of different doses of finasteride on prostate weight, spermatogenesis and fertility in mice. Eighty mature fertile male mice between 8-12 weeks age were used divided into four groups every group consist of 20 males. First group (control group G1) received distil water only (low dose group G2) treated with finasteride (0.006) mg/daily dose, (recommended dose group G3) treated with finasteride (0.03) mg/daily dose and last (double dose group; G4) treated with finasteride (0.06) mg/daily dose orally administrated mice for 90 days for all treated groups. After 90 days of treatment, the mating was achieved. Recording new borns in four groups, after then sacrifice male mice in four groups and remove testis and prostate whereas prostate weight detected for male to observe the differences, and testis for histological study, the specimens independently read. Evaluate histology of testis to observe the process of spermatogenesis in the testis of each group. Results: It showed that there are effects of finasteride on morphology and histology of testis as well as spermatogenesis of all groups.  The effects of finasteride on fertility by reduce rate of newborns and also effects on psychological behaviors included reduces aggressive in male mice and finally the effects on body weight where as it caused a slight body weight gain. The results concluded after treatment with finasteride during 90 days there was alteration of prostate weight and shrinking in size without effect on spermatogenesis, as well as, histological change occurs in testis, that effect on male fertility, also there is change on psychological behaviors of male mice.

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