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Figure data: Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.

Andrés-Delgado, Laura; Ernst, Alexander; Galardi-Castilla, María; Bazaga, David; Peralta, Marina; Münch, Juliane; González-Rosa, Juan Manuel; Tessadori, Federico; de la Pompa, José Luis; Vermot, Julien; Mercader, Nadia


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  <identifier identifierType="URL">https://zenodo.org/record/3247911</identifier>
  <creators>
    <creator>
      <creatorName>Andrés-Delgado, Laura</creatorName>
      <givenName>Laura</givenName>
      <familyName>Andrés-Delgado</familyName>
      <affiliation>Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, SpainDepartment of Anatomy, Histology and Neuroscience. School of Medicine. Autonoma University of Madrid. Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Ernst, Alexander</creatorName>
      <givenName>Alexander</givenName>
      <familyName>Ernst</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-9979-8002</nameIdentifier>
      <affiliation>Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland.</affiliation>
    </creator>
    <creator>
      <creatorName>Galardi-Castilla,  María</creatorName>
      <givenName>María</givenName>
      <familyName>Galardi-Castilla</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2455-6671</nameIdentifier>
      <affiliation>Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Bazaga, David</creatorName>
      <givenName>David</givenName>
      <familyName>Bazaga</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-5758-8402</nameIdentifier>
      <affiliation>Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Peralta, Marina</creatorName>
      <givenName>Marina</givenName>
      <familyName>Peralta</familyName>
      <affiliation>Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, SpainInstitute of Genetics and Molecular and Cellular Biology (IGBMC), 67404 Illkirch, France</affiliation>
    </creator>
    <creator>
      <creatorName>Münch, Juliane</creatorName>
      <givenName>Juliane</givenName>
      <familyName>Münch</familyName>
      <affiliation>Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, SpainCiber CV, 28029, Madrid, SpainPresent address: Institute of Biochemistry and Biology, Potsdam University, Karl-Liebknecht-Straße 24-25, Potsdam D-14476, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>González-Rosa, Juan Manuel</creatorName>
      <givenName>Juan Manuel</givenName>
      <familyName>González-Rosa</familyName>
      <affiliation>Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, SpainPresent address: Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA</affiliation>
    </creator>
    <creator>
      <creatorName>Tessadori, Federico</creatorName>
      <givenName>Federico</givenName>
      <familyName>Tessadori</familyName>
      <affiliation>Hubrecht Institute-KNAW and UMC Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>de la Pompa, José Luis</creatorName>
      <givenName>José Luis</givenName>
      <familyName>de la Pompa</familyName>
      <affiliation>Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, SpainCiber CV, 28029, Madrid, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Vermot, Julien</creatorName>
      <givenName>Julien</givenName>
      <familyName>Vermot</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-8924-732X</nameIdentifier>
      <affiliation>Institute of Genetics and Molecular and Cellular Biology (IGBMC), 67404 Illkirch, France</affiliation>
    </creator>
    <creator>
      <creatorName>Mercader, Nadia</creatorName>
      <givenName>Nadia</givenName>
      <familyName>Mercader</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0905-6399</nameIdentifier>
      <affiliation>Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, SpainInstitute of Anatomy, University of Bern, 3000 Bern 9, Switzerland</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Figure data: Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-06-07</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Dataset"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3247911</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1242/dev.174961</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis it arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using the zebrafish model and a combination of genetic tools, pharmacological agents and quantitative &lt;em&gt;in vivo&lt;/em&gt; imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that BMP signaling and the actomyosin cytoskeleton promote constriction of the DP, which enabled PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil the developmental fate to form a new tissue layer, the epicardium.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100001711</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/SNSF/Project+funding/310030E-164245/">310030E-164245</awardNumber>
      <awardTitle>The Cellular Basis of Cardiac Development Revealead by Live Imaging</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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