Dataset Open Access

Movie files: Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.

Andrés-Delgado, Laura; Ernst, Alexander; Galardi-Castilla, María; Bazaga, David; Peralta, Marina; Münch, Juliane; González-Rosa, Juan Manuel; Tessadori, Federico; e la Pompa, José Luis; Vermot, Julien; Mercader, Nadia


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    <subfield code="u">Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, SpainCiber CV, 28029, Madrid, SpainPresent address: Institute of Biochemistry and Biology, Potsdam University, Karl-Liebknecht-Straße 24-25, Potsdam D-14476, Germany</subfield>
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    <subfield code="u">Development of the epicardium and its role during regeneration laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, SpainDepartment of Anatomy, Histology and Neuroscience. School of Medicine. Autonoma University of Madrid. Spain</subfield>
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    <subfield code="a">&lt;p&gt;The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis it arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using the zebrafish model and a combination of genetic tools, pharmacological agents and quantitative &lt;em&gt;in vivo&lt;/em&gt; imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that BMP signaling and the actomyosin cytoskeleton promote constriction of the DP, which enabled PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil the developmental fate to form a new tissue layer, the epicardium.&lt;/p&gt;</subfield>
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