10.5281/zenodo.3226985
https://zenodo.org/records/3226985
oai:zenodo.org:3226985
gnd:2019-03334
Steven John Shabel
Steven John Shabel
Departments of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390
Chenyu Wang
Chenyu Wang
Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94143
Bradley Monk
Bradley Monk
Cognitive Sciences IDP, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093
Sage Aronson
Sage Aronson
Neuroscience Graduate Program, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093
Roberto Malinow
Roberto Malinow
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093
Stress transforms lateral habenula reward responses into punishment signals
Zenodo
2019
Stress, habenula, reward, punishment
2019-05-23
eng
10.5281/zenodo.3226984
v001
Creative Commons Attribution 4.0 International
Neuronal activity in the lateral habenula (LHb), a brain region implicated in depression, decreases during reward and increases during punishment or reward omission. While stress is a major risk factor for depression and strongly impacts the LHb, its effect on LHb reward signals is unknown. Here we image LHb neuronal activity in behaving mice and find that acute stress transforms LHb reward responses into punishment-like neural signals; punishment-like responses to reward omission also increase. These neural changes matched the onset of anhedonic behavior and were specific to LHb neurons that distinguished reward and its omission. Thus, stress distorts LHb responsivity to positive and negative feedback, which could bias individuals towards negative expectations, a key aspect of the proposed pathogenesis of depression