May 15, 2019 Preprint Open Access

Höchenberger, Richard; Ohla, Kathrin

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{
  "description": "<p>The ability to smell is crucial for most species as it enables the detection of environmental&nbsp;threats like smoke, fosters social interactions, and contributes to the sensory evaluation of food&nbsp;and eating behavior. The high prevalence of smell disturbances throughout the life span calls&nbsp;for a continuous effort to improve tools for quick and reliable assessment of olfactory function.&nbsp;Odor-dispensing pens, called Sniffin&rsquo; Sticks, are an established method to deliver olfactory stimuli&nbsp;during diagnostic evaluation. We tested the suitability of a Bayesian adaptive algorithm (QUEST) to&nbsp;estimate olfactory sensitivity using Sniffin&rsquo; Sticks by comparing QUEST sensitivity thresholds with&nbsp;those obtained using a procedure based on an established standard staircase protocol. Thresholds&nbsp;were measured twice with both procedures in two sessions (Test and Retest). Overall, both procedures&nbsp;exhibited considerable overlap with QUEST displaying slightly higher test-retest correlations, less&nbsp;variability between measurements, and reduced testing duration. Notably, participants were more&nbsp;frequently presented with the highest concentration during the QUEST which may foster adaptation&nbsp; and habituation effects. We conclude that further research is required to better understand and&nbsp;optimize the procedure for&nbsp;assessment of olfactory performance.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Institute of Neuroscience and Medicine INM-3, Research Center J\u00fclich, J\u00fclich, Germany; Psychophysiology of Food Perception, German Institute of Human Nutrition Potsdam-Rehbr\u00fccke, Nuthetal, Germany", 
      "@id": "https://orcid.org/0000-0002-0380-4798", 
      "@type": "Person", 
      "name": "H\u00f6chenberger, Richard"
    }, 
    {
      "affiliation": "Institute of Neuroscience and Medicine INM-3, Research Center J\u00fclich, J\u00fclich, Germany; Psychophysiology of Food Perception, German Institute of Human Nutrition Potsdam-Rehbr\u00fccke, Nuthetal, Germany", 
      "@id": "https://orcid.org/0000-0001-7265-0449", 
      "@type": "Person", 
      "name": "Ohla, Kathrin"
    }
  ], 
  "headline": "Estimation of olfactory sensitivity using a Bayesian adaptive method", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2019-05-15", 
  "url": "https://zenodo.org/record/2840358", 
  "keywords": [
    "smell sensitivity", 
    "olfaction", 
    "threshold", 
    "staircase", 
    "QUEST"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.2840358", 
  "@id": "https://doi.org/10.5281/zenodo.2840358", 
  "@type": "ScholarlyArticle", 
  "name": "Estimation of olfactory sensitivity using a Bayesian adaptive method"
}