2604712
doi
10.5281/zenodo.2604712
oai:zenodo.org:2604712
Ihim S. A.
Department of Pharmacology andToxicology, Faculty of Pharmaceutical Sciences, Nsukka, 410001, Enugu State, Nigeria.
Akah P. A.
Department of Pharmacology andToxicology, Faculty of Pharmaceutical Sciences, Nsukka, 410001, Enugu State, Nigeria.
Hepatoprotective effect of the methanol leaf extract of Lophira lanceolata teigh (Ochnaceae): An experimental study
Onyeto C. A
Department of Pharmacology andToxicology, Faculty of Pharmaceutical Sciences, Nsukka, 410001, Enugu State, Nigeria.
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Hepato-protective effect, Lophiralanceolata, methanol extract, rats, carbon tetrachloride
<p><strong>The hepatoprotective effect of methanol leaf extract (ME) of <em>Lophiralanceolata </em>Tiegh (Ochnaceae) was investigated against carbon tetrachloride (CCI<sub>4</sub>) induced hepatotoxicity in rats. Rats were randomly divided into 7 groups(n=6) and ME were administered at 100, 200, and 400mg/kg/day p.o to groups III-V, while groups I, VI and VII received 1ml/kg tween 80, Vitamin C and Silymarin at 25 mg/kg/day p.o respectively while group II received only CCl<sub>4.. </sub>CCI<sub>4</sub> was given every 72 hours to all the groups except group1.ThenSerum level of blood samples was assayed by alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), malondialdehyde (MDA), total protein, total bilirubin, albumin and globulin. ME significantly (p < 0.05) reduced in the serum levels of the liver enzymes when compared with the control group (CCI<sub>4</sub>). The levels of ALT, AST and bilirubin at 100 and 400mg/kg were reduced significantly (p< 0.05).Also, ALP levels was lowered at 100 mg/kg but not significant difference (p>0.05). At 100mg/kg, MDA levels was lowered more significantly (p<0.05) than controls (Silymarin and vitamin C).Serum globulin level at 200mg/kg dose of extract was significantly increased when compared to CCI<sub>4 </sub>control group.</strong></p>
<p><strong>In conclusion, ME can be protective against oxidative stress caused by liver toxicitylike CCl<sub>4.</sub></strong></p>
Zenodo
2019-03-24
info:eu-repo/semantics/article
2604711
1579533724.646771
120390
md5:1da6d4be91bf6c5a31fc73cf887c44d7
https://zenodo.org/records/2604712/files/Onyeto et al.pdf
public
10.5281/zenodo.2604711
isVersionOf
doi