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DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF KETOPROFEN IN CAPSULE AND TABLET DOSAGE FORMS

A. A. Hassan1, S. W. Shantier2*, E. A.Gad-kariem2


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    <subfield code="u">1Department of Pharmaceutical Chemistry, Ribat University, Khartoum, Sudan. 2Department of Pharmaceutical Chemistry, University of Khartoum, P.O. Box 1996, Khartoum, Sudan.</subfield>
    <subfield code="a">A. A. Hassan1, S. W. Shantier2*, E. A.Gad-kariem2</subfield>
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    <subfield code="a">&lt;p&gt;A simple and sensitive UV-spectrophotometric method for the assay of the poorly water-soluble ketoprofen in its dosage form was developed using 1M NaHCO3 as diluent. Ketoprofen exhibited maximum absorbance at 260 nm. Validation of the method was performed according to ICH guidelines. It was found to be linear in the concentration range of 2.5-15 &amp;mu;g/ml (R2=0.998) with low values of limit of detection and quantification (0.78&amp;mu;g/ml, 2.35&amp;mu;g/ml).The application of the proposed method for assay of ketoprofen (tablets and capsules) gave good results 99.08%&amp;plusmn;0.58 and 99.28%&amp;plusmn; 0.82, respectively.&lt;/p&gt;</subfield>
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