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Clotrimazole is a synthetic, imidazole derivate with broad-spectrum, antifungal drug which has been used in many skin and nail infections caused by fungi. The aim of the present study is to prepare and evaluate novel topical drug delivery of clotrimazole by using pluronic lecithin based organogel. Formulations were developed using 30% oil phase and 70% aqueous phase. The formulated organogels were evaluated for appearance by psycho-rheological, in vitro diffusion study, drug content, viscosity, spreadability and pH. It was found that the pH of all the formulations is in the range of to 6-7 that suits the skin pH, indicating skin compatibility. This is the primary requirement for a good topical formulation. All formulation showed spreadability in the range of 13.83- 28.35gcm/sec. The finding of the study can be utilize for the development of organogel of the other drugs for the safer and effective topical delivery.
", "publication_date": "2019-02-04", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Pluronic Lecithin Organogel, Clotrimazole, Topical Delivery." } ], "title": "FORMULATION AND EVALUATION OF PLURONIC LECITHIN CLOTRIMAZOLE ORGANOGEL FOR TOPICAL DELIVERY" }, "parent": { "access": { "owned_by": { "user": 35756 } }, "communities": { "default": "771e8d7c-d985-41ac-8e4e-6c99aad567fc", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2017-09-13T19:18:48.802131+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "771e8d7c-d985-41ac-8e4e-6c99aad567fc", "links": {}, "metadata": { "curation_policy": "How your submission is handled:
\r\n\r\nIndo American Journal of Pharmaceutical Research is a forum for ideas providing an international platform directed towards addressing needs of academic, industrial, clinical and government by publishing original research articles, review articles & short communications in the field of pharmaceutical science. IAJPR is Monthly journal which showcases important research articles on topic of high current interest that foster the diversity and debate upon which the scientific process thrives.
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IAJPR has been screened and acknowledged by all major Indian universities for PG & PhD Research for its Plagiarism prevention and detection policy, Scientific & conceptual evaluation process.
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