FORMULATION AND EVALUATION OF PLURONIC LECITHIN CLOTRIMAZOLE ORGANOGEL FOR TOPICAL DELIVERY

Clotrimazole is a synthetic, imidazole derivate with broad-spectrum, antifungal drug which has been used in many skin and nail infections caused by fungi. The aim of the present study is to prepare and evaluate novel topical drug delivery of clotrimazole by using pluronic lecithin based organogel. Formulations were developed using 30% oil phase and 70% aqueous phase. The formulated organogels were evaluated for appearance by psycho-rheological, in vitro diffusion study, drug content, viscosity, spreadability and pH. It was found that the pH of all the formulations is in the range of to 6-7 that suits the skin pH, indicating skin compatibility. This is the primary requirement for a good topical formulation. All formulation showed spreadability in the range of 13.83- 28.35gcm/sec. The finding of the study can be utilize for the development of organogel of the other drugs for the safer and effective topical delivery.