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SUMCASTEC_190201_NA_BangorWSPres_Workshop Presentation_.pdf_Limoges_S. Saada_Public_NA

S. Saada; B. Bessette; G. Begau; S. Battu; F. Lalloue


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@misc{s_saada_2019_2555150,
  author       = {S. Saada and
                  B. Bessette and
                  G. Begau and
                  S. Battu and
                  F. Lalloue},
  title        = {{SUMCASTEC_190201_NA_BangorWSPres_Workshop 
                   Presentation_.pdf_Limoges_S. Saada_Public_NA}},
  month        = feb,
  year         = 2019,
  note         = {{Abstract of the talk: The cancer stem cell (CSC) 
                   concept was proposed since decades to explain
                   treatment resistance and tumor recurrences. It is
                   currently admitted the presence of the CSCs in
                   many tumors. CSCs are subpopulation of cells
                   present in the heterogeneous tumor mass in
                   specific tumoral niches. The presence of CSCs
                   explains the clinical observations of tumor
                   recurrences after supposed successful therapies
                   (chemo- and/or radiotherapies). The acknowledge of
                   CSCs properties, including plasticity, quiescence
                   and auto-renewal is in perpetual increase. Despite
                   the techniques evolutions, their identification,
                   isolation and characterization are still very
                   difficult. CSC identification is based on the
                   presence of set of cell-undifferentiated
                   biological markers such as CD133, CD44 and some
                   transcription factors Oct4, Sox2, Nanog...
                   however, these markers are common to the normal
                   stem cells, and are unable to specifically isolate
                   CSCs. Even, using isolation of CSCs based on CD133
                   positive cells is the most frequently used
                   strategy, using this unique marker is still
                   controversial, and its efficiency is not
                   completely admitted. Since their presence carries
                   the aggressiveness character and properties of
                   many human tumors, their identification and
                   isolation are critical in future therapeutic
                   strategies of tumor eradication.}},
  doi          = {10.5281/zenodo.2555150},
  url          = {https://doi.org/10.5281/zenodo.2555150}
}
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