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SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES

Shrinivas D. Joshi1*, V. H. Kulkarni1, S. R. Prem Kumar1, Jeelan Basha2.


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Shrinivas D. Joshi1*, V. H. Kulkarni1, S. R. Prem Kumar1, Jeelan Basha2.</dc:creator>
  <dc:date>2019-01-31</dc:date>
  <dc:description>Novel series of pyrrolylbenzamide derivatives were synthesized with an aim to combat the increasing anti-tubercular resistance and to develop more potent anti-tubercular agents with reasonably less side effect. Herein, we synthesized a series of substituted 2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides (3a-f) by reacting different substituted aromatic acids with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline (2) by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Structures of all the newly synthesized compounds were established by spectral analysis viz., IR, 1H NMR, 13C NMR and Mass. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity.</dc:description>
  <dc:identifier>https://zenodo.org/record/2553823</dc:identifier>
  <dc:identifier>10.5281/zenodo.2553823</dc:identifier>
  <dc:identifier>oai:zenodo.org:2553823</dc:identifier>
  <dc:relation>doi:10.5281/zenodo.2553822</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/iajpr</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:subject>Dimethylpyrrole, Antitubercular agents, HBTU, DIEA, Benzamides.</dc:subject>
  <dc:title>SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
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