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SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES

Shrinivas D. Joshi1*, V. H. Kulkarni1, S. R. Prem Kumar1, Jeelan Basha2.


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{
  "description": "<p>Novel series of pyrrolylbenzamide derivatives were synthesized with an aim to combat the increasing anti-tubercular resistance and to develop more potent anti-tubercular agents with reasonably less side effect. Herein, we synthesized a series of substituted 2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides (3a-f) by reacting different substituted aromatic acids with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline (2) by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Structures of all the newly synthesized compounds were established by spectral analysis viz., IR, 1H NMR, 13C NMR and Mass. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity.</p>", 
  "license": "http://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "1Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S.E.T's College of Pharmacy, SangolliRayanna Nagar, Dharwad 580 002, India. 2Department of PG Studies and Research in Chemistry, Vijayanagar College, Hosapete, Karnataka, India.", 
      "@type": "Person", 
      "name": "Shrinivas D. Joshi1*, V. H. Kulkarni1, S. R. Prem Kumar1, Jeelan Basha2."
    }
  ], 
  "url": "https://zenodo.org/record/2553823", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2019-01-31", 
  "headline": "SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES", 
  "keywords": [
    "Dimethylpyrrole, Antitubercular agents, HBTU, DIEA, Benzamides."
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.2553823", 
  "@id": "https://doi.org/10.5281/zenodo.2553823", 
  "@type": "ScholarlyArticle", 
  "name": "SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES"
}
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