Journal article Open Access

SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES

Shrinivas D. Joshi1*, V. H. Kulkarni1, S. R. Prem Kumar1, Jeelan Basha2.


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.2553823", 
  "title": "SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        31
      ]
    ]
  }, 
  "abstract": "<p>Novel series of pyrrolylbenzamide derivatives were synthesized with an aim to combat the increasing anti-tubercular resistance and to develop more potent anti-tubercular agents with reasonably less side effect. Herein, we synthesized a series of substituted 2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides (3a-f) by reacting different substituted aromatic acids with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline (2) by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Structures of all the newly synthesized compounds were established by spectral analysis viz., IR, 1H NMR, 13C NMR and Mass. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity.</p>", 
  "author": [
    {
      "family": "Shrinivas D. Joshi1*, V. H. Kulkarni1, S. R. Prem Kumar1, Jeelan Basha2."
    }
  ], 
  "type": "article-journal", 
  "id": "2553823"
}
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