TKPlate: R package prototype for TK models graphical interface
- 1. Analytica Laser, a Certara company
- 2. EFSA
Description
Included in this upload is an R package httkgui
. It was a proof of concept for TKPlate, a graphical user interface (GUI) modification of a popular CRAN toxicokinetics R package httk
(v1.4); httkgui
modifies some of the TK models, allows rudimentary Monte Carlo simulations of said models and provides GUI (TKPlate) to run them and review the results. The original 'httk' (v1.8 as of Jan 2019) package is by John Wambaugh.
Source code (httkgui.zip) and Windows binary (httkgui1.0.zip) are included, together with a git repository of the project. This prototype doesn't include updated documentation, which may be added at a later time. All generic models in C are available in folder src/. The models modified by the authors are analogous to C models which are already included in httk.
To run the GUI prototype, type in pbtkUI() after installing the package.
The code modifications to 'httk' have been developed by Witold Wiecek with concept by Nadia Quignot and Billy Amzal at Analytica Laser (now Certara) and Jean-Lou Dorne (EFSA) as a part of an European Food Safety Authority project "Integrating toxicokinetics in chemical risk assessment: application to human, animal and environmental risk assessment" (OC/EFSA/SCER/2014/06)
Notes
Files
httkgui.zip
Files
(2.9 MB)
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