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Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA

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    <subfield code="x">Akgun FS, Karaarslan N, Yilmaz I, Ozbek H, Caliskan T, Ates O (2018). Systematic Evaluation of Adverse Reactions That May Occur After Injection of Type-A Botulinum Toxin in Patients with Spasmodic Torticollis Admitted to Emergency Department. Merit Res. J. Med. Med. Sci.;6(2): 68-72. Akyuva Y, Karaarslan N, Yilmaz I, Caliskan T, Sirin DY (2018). Will intervertebral disc diseases be prevented by siRNA ormiRNA-based genomic treatment modalities? Merit Res. J. Med. Med. Sci.;6(1):6- 15. Axelsson KF, Nilsson AG, Wedel H, Lundh D, Lorentzon M (2017). Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone.JAMA.;318(2):146-155. Bast A, Haenen GR (1992). The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. 2002; 11(3): 251-258. Busse E, Zimmer G, Schopohl B, Kornhuber B (1992). Influence of αlipoicacid on intracellular glutathione in vitroand in vivo. Arzneim - Forsch/DrugRes.; 42: 829-832. 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Yu X, Zhang D, Chen X, Yang J, Shi L, Pang Q (2018). Effectiveness of various hip preservation treatments for nontraumatic osteonecrosis of the femoral head: A network metaanalysis of randomized controlled trials. J Orthop. Sci. Mar;23(2):356-364.</subfield>
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    <subfield code="u">Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey.</subfield>
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    <subfield code="u">Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey.</subfield>
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    <subfield code="u">Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey</subfield>
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    <subfield code="a">Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head</subfield>
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    <subfield code="a">&lt;p&gt;Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer&amp;ndash;specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors.&amp;nbsp;&lt;/p&gt;</subfield>
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