Journal article Open Access

Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA


Dublin Core Export

<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>Yasin Emre KAYA</dc:contributor>
  <dc:creator>Yasin Emre KAYA</dc:creator>
  <dc:date>2018-12-22</dc:date>
  <dc:description>Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer–specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors. </dc:description>
  <dc:identifier>https://zenodo.org/record/2535585</dc:identifier>
  <dc:identifier>10.5281/zenodo.2535585</dc:identifier>
  <dc:identifier>oai:zenodo.org:2535585</dc:identifier>
  <dc:relation>doi:10.5281/zenodo.2535584</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:source>Merit Research Journal of Medicine and Medical Sciences 6(12) 426-4310</dc:source>
  <dc:subject>Endometrial carcinoma, endometrioid, E Cadherin, Her2/neu, and P53</dc:subject>
  <dc:title>Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
11
12
views
downloads
All versions This version
Views 1111
Downloads 1212
Data volume 2.1 MB2.1 MB
Unique views 55
Unique downloads 55

Share

Cite as