Yasin Emre KAYA
Yasin Emre KAYA
Yasin Emre KAYA
2018-12-22
<p>Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer–specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors. </p>
https://doi.org/10.5281/zenodo.2535585
oai:zenodo.org:2535585
Zenodo
https://doi.org/10.5281/zenodo.2535584
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Merit Research Journal of Medicine and Medical Sciences, 6(12), 426-4310, (2018-12-22)
Endometrial carcinoma, endometrioid, E Cadherin, Her2/neu, and P53
Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head
info:eu-repo/semantics/article