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Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA


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    "contributors": [
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        "affiliation": "Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey.", 
        "name": "Yasin Emre KAYA", 
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    "description": "<p>Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer&ndash;specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors.&nbsp;</p>", 
    "doi": "10.5281/zenodo.2535585", 
    "journal": {
      "issue": "12", 
      "pages": "426-4310", 
      "title": "Merit Research Journal of Medicine and Medical Sciences", 
      "volume": "6"
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    "keywords": [
      "Endometrial carcinoma, endometrioid, E Cadherin, Her2/neu, and P53"
    ], 
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      "id": "CC-BY-4.0"
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    "publication_date": "2018-12-22", 
    "references": [
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