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Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA


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  <identifier identifierType="DOI">10.5281/zenodo.2535585</identifier>
  <creators>
    <creator>
      <creatorName>Yasin Emre KAYA</creatorName>
      <affiliation>Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2018</publicationYear>
  <subjects>
    <subject>Endometrial carcinoma, endometrioid, E Cadherin, Her2/neu, and P53</subject>
  </subjects>
  <contributors>
    <contributor contributorType="ContactPerson">
      <contributorName>Yasin Emre KAYA</contributorName>
      <affiliation>Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey.</affiliation>
    </contributor>
    <contributor contributorType="Supervisor">
      <contributorName>Yasin Emre KAYA</contributorName>
      <affiliation>Abant Izzet Baysal University School of Medicine, Department of Orthopaedic and Traumatology, 14030, Bolu, Turkey.</affiliation>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Issued">2018-12-22</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/2535585</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.2535584</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer&amp;ndash;specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors.&amp;nbsp;&lt;/p&gt;</description>
    <description descriptionType="Other">{"references": ["Akgun FS, Karaarslan N, Yilmaz I, Ozbek H, Caliskan T, Ates O (2018). Systematic Evaluation of Adverse Reactions That May Occur After Injection of Type-A Botulinum Toxin in Patients with Spasmodic Torticollis Admitted to Emergency Department. Merit Res. J. Med. Med. Sci.;6(2): 68-72. Akyuva Y, Karaarslan N, Yilmaz I, Caliskan T, Sirin DY (2018). Will intervertebral disc diseases be prevented by siRNA ormiRNA-based genomic treatment modalities? Merit Res. J. Med. Med. Sci.;6(1):6- 15. Axelsson KF, Nilsson AG, Wedel H, Lundh D, Lorentzon M (2017). Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone.JAMA.;318(2):146-155. Bast A, Haenen GR (1992). The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. 2002; 11(3): 251-258. Busse E, Zimmer G, Schopohl B, Kornhuber B (1992). Influence of \u03b1lipoicacid on intracellular glutathione in vitroand in vivo. 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  </descriptions>
</resource>
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