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Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA


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{
  "DOI": "10.5281/zenodo.2535585", 
  "abstract": "<p>Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer&ndash;specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors.&nbsp;</p>", 
  "author": [
    {
      "family": "Yasin Emre KAYA"
    }
  ], 
  "container_title": "Merit Research Journal of Medicine and Medical Sciences", 
  "id": "2535585", 
  "issue": "12", 
  "issued": {
    "date-parts": [
      [
        2018, 
        12, 
        22
      ]
    ]
  }, 
  "page": "426-4310", 
  "publisher": "Zenodo", 
  "title": "Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head", 
  "type": "article-journal", 
  "volume": "6"
}
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