2530466
doi
10.5281/zenodo.2530466
oai:zenodo.org:2530466
user-iajpr
INVITRO ANTIOXIDANT CAPACITY AND FREE RADICAL SCAVENGING ACTIVITY OF VARIOUS ANTI DEPRESSANT DRUGS
Abhijit De*1, Manisha Singh2, Partha Chattopadhyay3
1Bengal School of Technology, Hooghly, West Bengal, India. 2Dr. Hari Singh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. 3National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India.
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
DPPH, FRAP, Lipid Peroxidation, Oxidative Stress, Reuptake Inhibitors.
<p>One of the major cause of depression and propagation of depression is oxidative stress and this leads to further complications like Parkinson’s disease, Alzheimer’s disease and other neurodegenerative conditions. Current study involved different reuptake inhibitors used in combating depression and the antioxidant activity. DPPH radical scavenging assay, Nitric oxide radical scavenging assay, FRAP, Phosphomolybdenum assay and assessment of inhibition of lipid peroxidation- these five methods were adopted for investigation of the antioxidant activity of Modafinil, Fluoxetine, Duloxetine and Vilazodone. This study indicated Modafinil as best DPPH radical scavenger, vilazodone as the best scavenger of nitric oxide radicals, duloxetine as the drugs with best reducing potential and fluoxetine as the best drug to inhibit lipid peroxidation amongst the four drugs. These findings suggest that these reuptake inhibitors have the radical scavenging capacity which may show beneficial effect in controlling depression besides their established pharmacological profile.</p>
Zenodo
2018-11-30
info:eu-repo/semantics/article
2530465
user-iajpr
1579542339.179619
884254
md5:a820fd5e3a16fcf65068d1d5c26d8560
https://zenodo.org/records/2530466/files/2.pdf
public
10.5281/zenodo.2530465
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doi