Journal article Open Access

INVITRO ANTIOXIDANT CAPACITY AND FREE RADICAL SCAVENGING ACTIVITY OF VARIOUS ANTI DEPRESSANT DRUGS

Abhijit De*1, Manisha Singh2, Partha Chattopadhyay3


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        <foaf:name>Abhijit De*1, Manisha Singh2, Partha Chattopadhyay3</foaf:name>
        <foaf:givenName>Manisha Singh2, Partha Chattopadhyay3</foaf:givenName>
        <foaf:familyName>Abhijit De*1</foaf:familyName>
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            <foaf:name>1Bengal School of Technology, Hooghly, West Bengal, India. 2Dr. Hari Singh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. 3National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India.</foaf:name>
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    <dct:title>INVITRO ANTIOXIDANT CAPACITY AND FREE RADICAL SCAVENGING ACTIVITY OF VARIOUS ANTI DEPRESSANT DRUGS</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2018</dct:issued>
    <dcat:keyword>DPPH, FRAP, Lipid Peroxidation, Oxidative Stress, Reuptake Inhibitors.</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2018-11-30</dct:issued>
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    <dct:description>&lt;p&gt;One of the major cause of depression and propagation of depression is oxidative stress and this leads to further complications like Parkinson&amp;rsquo;s disease, Alzheimer&amp;rsquo;s disease and other neurodegenerative conditions. Current study involved different reuptake inhibitors used in combating depression and the antioxidant activity. DPPH radical scavenging assay, Nitric oxide radical scavenging assay, FRAP, Phosphomolybdenum assay and assessment of inhibition of lipid peroxidation- these five methods were adopted for investigation of the antioxidant activity of Modafinil, Fluoxetine, Duloxetine and Vilazodone. This study indicated Modafinil as best DPPH radical scavenger, vilazodone as the best scavenger of nitric oxide radicals, duloxetine as the drugs with best reducing potential and fluoxetine as the best drug to inhibit lipid peroxidation amongst the four drugs. These findings suggest that these reuptake inhibitors have the radical scavenging capacity which may show beneficial effect in controlling depression besides their established pharmacological profile.&lt;/p&gt;</dct:description>
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