Journal article Open Access

A BUOYANT APPROACH FOR RETENTIVE DRUG DELIVERY: FLOATING MICROSPHERES

Soniya Kashyap*, Shikha Yadav, Popin Kumar, Tulsi Bisht

Floating drug delivery systems are low density systems that float over the gastric content and remain buoyant in the stomach for a prolonged period of time. They enhance drug bioavailability, reduce drug wastage, and provide controlled drug delivery and better patient compliance. Several approaches are currently being used to prolong the GRT, including floating drug delivery systems (FDDS), also known as hydrodynammically balanced systems (HBS), swelling and expanding systems, high density systems, and other delayed gastric emptying devices. The methodologies used in the development of FDDS by formulating effervescent and non-effervescent floating tablet based on buoyancy mechanism. Floating drug delivery systems (FDDS) was to organize the recently focus on the principal mechanism of floatation to achieve gastric retention time. This review article on FDDS includes the different types of FDDS, polymers used in formulation of FDDS, methods for manufacturing of granules, evaluation parameters.

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