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DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CILNIDIPINE AND TELMISARTAN IN BULK AND DOSAGE FORM

Lalit Thakare*, Sufiyan Ahmad, V. M. Shastry


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    <subfield code="a">&lt;p&gt;Simple, rapid, sensitive, precise and specific UV spectrophotometric method for the determination of Cilnidipine (CIL) and Telmisartan (TEL) in bulk drug and pharmaceutical dosage form were developed and validated. A simple double beam UV spectrophotometric method has been developed and validated with different parameters such as linearity, precision, repeatability, limit of detection (LOD), Limit of Quantification (LOQ), accuracy as per ICH guidelines. UV-visible spectrophotometric method, measurement of absorption at maximum wavelength in 10 ml acetonitrile and volume make with water solvent system as reference CIL and TEL were found to be at 203 nm and 241nm respectively. The drug obeyed the Beer&amp;rsquo;s law and showed good correlation. Beer&amp;rsquo;s law was obeyed in concentration range 0.5-2.5 &amp;mu;g/ml for Cilnidipine and 2-10&amp;mu;g/ml for Telmisartan respectively with correlation coefficient was 0.999. The LOD and LOQ of CIL were found to be 0.317 (&amp;mu;g/ml) and 0.96 (&amp;mu;g/ml), TEL were found to be 0.67 (&amp;mu;g/ml) and 5.086 (&amp;mu;g/ml), respectively. Percentage assay of CIL and TEL in tablets. The proposed method is precise, accurate and reproducible and can be used for routine analysis of CIL and TEL in bulk and pharmaceutical dosage form.&lt;/p&gt;</subfield>
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