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Heat-shock protein (Hsp90) a group of molecular chaperones responsible for managing protein folding and quality control in cell environment. Hsp90 requires a series of co-chaperones to assemble into a super-chaperone complex for its function. The current study is piloted to perform antibacterial, antifungal, anti-inflammatory, anti-Parkinson’s and antioxidant activities of Hsp90 inhibitors. The compounds S30 and S47 were synthesized and the maximum tolerable dose was found to be 2000 mg/kg, animals were administered with a dose of 100 mg/kg bd. wt and 200 mg/kg bd. wt. From the results dose dependent reduction in symptoms like muscular rigidity, ptosis, tremor, bradykinesia, gait alteration, righting reflex, swim test and locomotor behavior were observed. The histopathological studies of drug treated also showed the restoration. The two test drugs S30 and S47 possess antibacterial, antifungal, anti-inflammatory, anti-Parkinson’s and antioxidant activities. Further study is needed to confirm the exact mechanism of action of the test drugs S30 and S47.
", "publication_date": "2017-04-30", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Hsp90, MIC, Antibacterial, Antifungal, Anti-Inflammatory, Anti-Parkinson's Activity, Antioxidant Activity." } ], "title": "ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTI-PARKINSON'S SCREENING OF AZOMETHINE ANALOGUES THROUGH HSP90 INHIBITION" }, "parent": { "access": { "owned_by": { "user": 35756 } }, "communities": { "default": "771e8d7c-d985-41ac-8e4e-6c99aad567fc", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2017-09-13T19:18:48.802131+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "771e8d7c-d985-41ac-8e4e-6c99aad567fc", "links": {}, "metadata": { "curation_policy": "How your submission is handled:
\r\n\r\nIndo American Journal of Pharmaceutical Research is a forum for ideas providing an international platform directed towards addressing needs of academic, industrial, clinical and government by publishing original research articles, review articles & short communications in the field of pharmaceutical science. IAJPR is Monthly journal which showcases important research articles on topic of high current interest that foster the diversity and debate upon which the scientific process thrives.
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IAJPR has been screened and acknowledged by all major Indian universities for PG & PhD Research for its Plagiarism prevention and detection policy, Scientific & conceptual evaluation process.
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