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The design of extended release tablet by using natural polymers are becoming very popular in formulating oral controlled release tablet as they are biocompatible, biodegradable, non-toxic, cheap and easily available compared to synthetic polymers. The present investigation was planned to formulate and evaluate the clarithromycin once daily extended release tablets with natural polymers like guar gum and xanthan gum and in combination with HPMC K15M. Drug- excipient compatibility study was conducted using FTIR spectroscopy. A total of seven formulations were prepared with different combinations of polymers using wet granulation and compression method. Pre compression and post compression parameters were tested and in vitro drug release study was performed and the data were fitted into kinetic models. The selected best formulation (F7) was kept for short-term accelerated stability studies (1 month at 40oC±2oC / 75%±5% RH). FTIR analysis of spectra showed that there are no drug-excipients interactions and all the formulated tablets had acceptable physical properties. Drug content uniformity, hardness and thickness of best formulation (F7) were found to be 99.7±0.004%, 4.8±0.21 Kg/cm2 and 4.9±0.002mm. Formulation (F7) showed release up to 94.81% in 0.1 N HCl and 88.4% in potassium phosphate buffer pH 6 in 24 hrs. The release mechanism of the best formulation (F7) was found to be non fickian and Fick’s law respectively, i.e., by both diffusion and erosion. It can be concluded that a successful once daily extended release tablets of Clarithromycin have been prepared by using the natural polymer such as guar gum.
", "publication_date": "2017-04-30", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "title": "FORMULATION AND EVALUATION OF CLARITHROMYCIN EXTENDED RELEASE TABLET" }, "parent": { "access": { "owned_by": { "user": 35756 } }, "communities": { "default": "771e8d7c-d985-41ac-8e4e-6c99aad567fc", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2017-09-13T19:18:48.802131+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "771e8d7c-d985-41ac-8e4e-6c99aad567fc", "links": {}, "metadata": { "curation_policy": "How your submission is handled:
\r\n\r\nIndo American Journal of Pharmaceutical Research is a forum for ideas providing an international platform directed towards addressing needs of academic, industrial, clinical and government by publishing original research articles, review articles & short communications in the field of pharmaceutical science. IAJPR is Monthly journal which showcases important research articles on topic of high current interest that foster the diversity and debate upon which the scientific process thrives.
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IAJPR has been screened and acknowledged by all major Indian universities for PG & PhD Research for its Plagiarism prevention and detection policy, Scientific & conceptual evaluation process.
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