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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE

Bhavini Milankumar Patel


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{
  "description": "<p>The present research work aims to develop a simple, precise, accurate, rapid, reproducible and economical method for the estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their synthetic mixture by RP-HPLC method. An absorbance maximum for this combination was found to be at 225 nm using methanol as a solvent. Development And Validation Of RP-HPLC method for estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their combined marketed dosage form was performed on a Hypersil BDS (250 x 4.6mm C18) column with mobile phase containing, buffer (pH 6.5-KH2PO4):Methanol in ratio of 50:50. The flow rate was 1 ml/min and the eluent was monitored at 225 nm. Detection was carried in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Fluocinolone acetonide and Ciprofloxacin hydrochloride at 3.33 and 4.77 min respectively.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Department of Quality Assurance, A-One Pharmacy College, Ahmedabad, Gujarat, India.", 
      "@type": "Person", 
      "name": "Bhavini Milankumar Patel"
    }
  ], 
  "headline": "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2017-04-30", 
  "url": "https://zenodo.org/record/2526045", 
  "keywords": [
    "RP-HPLC, Fluocinolone Acetonide, Ciprofloxacin Hydrochloride, Synthetic Mixture, Validation."
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.2526045", 
  "@id": "https://doi.org/10.5281/zenodo.2526045", 
  "@type": "ScholarlyArticle", 
  "name": "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE"
}
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