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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE

Bhavini Milankumar Patel


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  <identifier identifierType="DOI">10.5281/zenodo.2526045</identifier>
  <creators>
    <creator>
      <creatorName>Bhavini Milankumar Patel</creatorName>
      <affiliation>Department of Quality Assurance, A-One Pharmacy College, Ahmedabad, Gujarat, India.</affiliation>
    </creator>
  </creators>
  <titles>
    <title>DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2017</publicationYear>
  <subjects>
    <subject>RP-HPLC, Fluocinolone Acetonide, Ciprofloxacin Hydrochloride, Synthetic Mixture, Validation.</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2017-04-30</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/2526045</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.2526044</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/iajpr</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The present research work aims to develop a simple, precise, accurate, rapid, reproducible and economical method for the estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their synthetic mixture by RP-HPLC method. An absorbance maximum for this combination was found to be at 225 nm using methanol as a solvent. Development And Validation Of RP-HPLC method for estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their combined marketed dosage form was performed on a Hypersil BDS (250 x 4.6mm C18) column with mobile phase containing, buffer (pH 6.5-KH2PO4):Methanol in ratio of 50:50. The flow rate was 1 ml/min and the eluent was monitored at 225 nm. Detection was carried in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Fluocinolone acetonide and Ciprofloxacin hydrochloride at 3.33 and 4.77 min respectively.&lt;/p&gt;</description>
  </descriptions>
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