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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE

Bhavini Milankumar Patel


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        <foaf:name>Bhavini Milankumar Patel</foaf:name>
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            <foaf:name>Department of Quality Assurance, A-One Pharmacy College, Ahmedabad, Gujarat, India.</foaf:name>
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    <dct:title>DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2017</dct:issued>
    <dcat:keyword>RP-HPLC, Fluocinolone Acetonide, Ciprofloxacin Hydrochloride, Synthetic Mixture, Validation.</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2017-04-30</dct:issued>
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    <dct:description>&lt;p&gt;The present research work aims to develop a simple, precise, accurate, rapid, reproducible and economical method for the estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their synthetic mixture by RP-HPLC method. An absorbance maximum for this combination was found to be at 225 nm using methanol as a solvent. Development And Validation Of RP-HPLC method for estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their combined marketed dosage form was performed on a Hypersil BDS (250 x 4.6mm C18) column with mobile phase containing, buffer (pH 6.5-KH2PO4):Methanol in ratio of 50:50. The flow rate was 1 ml/min and the eluent was monitored at 225 nm. Detection was carried in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Fluocinolone acetonide and Ciprofloxacin hydrochloride at 3.33 and 4.77 min respectively.&lt;/p&gt;</dct:description>
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