Journal article Open Access

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE

Bhavini Milankumar Patel


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.2526045", 
  "author": [
    {
      "family": "Bhavini Milankumar Patel"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2017, 
        4, 
        30
      ]
    ]
  }, 
  "abstract": "<p>The present research work aims to develop a simple, precise, accurate, rapid, reproducible and economical method for the estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their synthetic mixture by RP-HPLC method. An absorbance maximum for this combination was found to be at 225 nm using methanol as a solvent. Development And Validation Of RP-HPLC method for estimation of Fluocinolone acetonide and Ciprofloxacin hydrochloride in their combined marketed dosage form was performed on a Hypersil BDS (250 x 4.6mm C18) column with mobile phase containing, buffer (pH 6.5-KH2PO4):Methanol in ratio of 50:50. The flow rate was 1 ml/min and the eluent was monitored at 225 nm. Detection was carried in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Fluocinolone acetonide and Ciprofloxacin hydrochloride at 3.33 and 4.77 min respectively.</p>", 
  "title": "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND FLUOCINOLONE ACETONIDE IN THEIR SYNTHETIC MIXTURE", 
  "type": "article-journal", 
  "id": "2526045"
}
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