Journal article Open Access

A specific dietary intervention to restore brain structure and function after ischemic stroke.

Wiesmann, Maximilian; Zinnhardt, Bastian; Reinhardt, Dirk; Eligehausen, Sarah; Wachsmuth, Lydia; Hermann, Sven; Dederen, Pieter J; Hellwich, Marloes; Kuhlmann, Michael T; Broersen, Laus; Heerschap, Arend; Jacobs, Andreas H; Kiliaan, Amanda J


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    <subfield code="u">Department of Clinical Radiology of the University Hospital, Westfälische Wilhelms University Münster, Münster, Germany</subfield>
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    <subfield code="a">A specific dietary intervention to restore brain structure and function after ischemic stroke.</subfield>
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    <subfield code="a">&lt;p&gt;Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic&lt;br&gt;
stroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core&lt;br&gt;
and an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable&lt;br&gt;
tissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in&lt;br&gt;
this cross-institutional study we investigated the neurorestorative efficacy of a dietary approach&lt;br&gt;
(Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline,&lt;br&gt;
phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to&lt;br&gt;
counteract neuroinflammation and impairments of cerebral (structural+functional) connectivity,&lt;br&gt;
cerebral blood flow (CBF), and motor function. Male adult C57BL/6j mice were subjected to right&lt;br&gt;
tMCAo using the intraluminal filament model. Following tMCAo, animals were either maintained&lt;br&gt;
on Control diet or switched to the multicomponent Fortasyn diet. At several time points after&lt;br&gt;
tMCAo, behavioral tests, and MRI and PET scanning were conducted to identify the impact of the&lt;br&gt;
multicomponent diet on the elicited neuroinflammatory response, loss of cerebral connectivity,&lt;br&gt;
and the resulting impairment of motor function after experimental stroke. Mice on the&lt;br&gt;
multicomponent diet showed decreased neuroinflammation, improved functional and structural&lt;br&gt;
connectivity, beneficial effect on CBF, and also improved motor function after tMCAo. Our&lt;br&gt;
present data show that this specific dietary intervention may have beneficial effects&lt;/p&gt;</subfield>
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