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A specific dietary intervention to restore brain structure and function after ischemic stroke.

Wiesmann, Maximilian; Zinnhardt, Bastian; Reinhardt, Dirk; Eligehausen, Sarah; Wachsmuth, Lydia; Hermann, Sven; Dederen, Pieter J; Hellwich, Marloes; Kuhlmann, Michael T; Broersen, Laus; Heerschap, Arend; Jacobs, Andreas H; Kiliaan, Amanda J


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    "doi": "10.7150/thno.17559", 
    "description": "<p>Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic<br>\nstroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core<br>\nand an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable<br>\ntissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in<br>\nthis cross-institutional study we investigated the neurorestorative efficacy of a dietary approach<br>\n(Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline,<br>\nphospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to<br>\ncounteract neuroinflammation and impairments of cerebral (structural+functional) connectivity,<br>\ncerebral blood flow (CBF), and motor function. Male adult C57BL/6j mice were subjected to right<br>\ntMCAo using the intraluminal filament model. Following tMCAo, animals were either maintained<br>\non Control diet or switched to the multicomponent Fortasyn diet. At several time points after<br>\ntMCAo, behavioral tests, and MRI and PET scanning were conducted to identify the impact of the<br>\nmulticomponent diet on the elicited neuroinflammatory response, loss of cerebral connectivity,<br>\nand the resulting impairment of motor function after experimental stroke. Mice on the<br>\nmulticomponent diet showed decreased neuroinflammation, improved functional and structural<br>\nconnectivity, beneficial effect on CBF, and also improved motor function after tMCAo. Our<br>\npresent data show that this specific dietary intervention may have beneficial effects</p>", 
    "license": {
      "id": "CC-BY-4.0"
    }, 
    "title": "A specific dietary intervention to restore brain structure and function after ischemic stroke.", 
    "journal": {
      "volume": "7", 
      "issue": "2", 
      "pages": "493-512", 
      "title": "Theranostics"
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        "code": "278850", 
        "links": {
          "self": "https://zenodo.org/api/grants/10.13039/501100000780::278850"
        }, 
        "title": "Imaging of Neuroinflammation in Neurodegenerative Diseases", 
        "acronym": "INMIND", 
        "program": "FP7", 
        "funder": {
          "doi": "10.13039/501100000780", 
          "acronyms": [
            "EC"
          ], 
          "name": "European Commission", 
          "links": {
            "self": "https://zenodo.org/api/funders/10.13039/501100000780"
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    ], 
    "keywords": [
      "Cerebral Ischemia", 
      "Neuroinflammation", 
      "Cerebral Connectivity", 
      "Cerebral Blood Flow", 
      "MRI", 
      "PET", 
      "Animal Model"
    ], 
    "publication_date": "2017-01-06", 
    "creators": [
      {
        "affiliation": "Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands and Department of Geriatric Medicine, Radboud university medical center, Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands", 
        "name": "Wiesmann, Maximilian"
      }, 
      {
        "affiliation": "European Institute for Molecular Imaging (EIMI), Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany", 
        "name": "Zinnhardt, Bastian"
      }, 
      {
        "affiliation": "European Institute for Molecular Imaging (EIMI), Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany", 
        "name": "Reinhardt, Dirk"
      }, 
      {
        "affiliation": "European Institute for Molecular Imaging (EIMI), Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany", 
        "name": "Eligehausen, Sarah"
      }, 
      {
        "affiliation": "Department of Clinical Radiology of the University Hospital, Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany", 
        "name": "Wachsmuth, Lydia"
      }, 
      {
        "affiliation": "European Institute for Molecular Imaging (EIMI), Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany", 
        "name": "Hermann, Sven"
      }, 
      {
        "affiliation": "Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands", 
        "name": "Dederen, Pieter J"
      }, 
      {
        "affiliation": "Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands", 
        "name": "Hellwich, Marloes"
      }, 
      {
        "affiliation": "European Institute for Molecular Imaging (EIMI), Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany", 
        "name": "Kuhlmann, Michael T"
      }, 
      {
        "affiliation": "Advanced Medical Nutrition, Nutricia Research, Utrecht, The Netherlands", 
        "name": "Broersen, Laus"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, Radboud university medical center, Nijmegen, The Netherlands", 
        "name": "Heerschap, Arend"
      }, 
      {
        "affiliation": "European Institute for Molecular Imaging (EIMI), Westf\u00e4lische Wilhelms University M\u00fcnster, M\u00fcnster, Germany and Department of Geriatrics, Johanniter Hospital, Evangelische Kliniken, Bonn, Germany", 
        "name": "Jacobs, Andreas H"
      }, 
      {
        "affiliation": "Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands", 
        "name": "Kiliaan, Amanda J"
      }
    ], 
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