Journal article Open Access

A specific dietary intervention to restore brain structure and function after ischemic stroke.

Wiesmann, Maximilian; Zinnhardt, Bastian; Reinhardt, Dirk; Eligehausen, Sarah; Wachsmuth, Lydia; Hermann, Sven; Dederen, Pieter J; Hellwich, Marloes; Kuhlmann, Michael T; Broersen, Laus; Heerschap, Arend; Jacobs, Andreas H; Kiliaan, Amanda J


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  <identifier identifierType="URL">https://zenodo.org/record/247065</identifier>
  <creators>
    <creator>
      <creatorName>Wiesmann, Maximilian</creatorName>
      <givenName>Maximilian</givenName>
      <familyName>Wiesmann</familyName>
      <affiliation>Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition &amp; Behaviour, Nijmegen, The Netherlands and Department of Geriatric Medicine, Radboud university medical center, Donders Institute for Brain, Cognition &amp; Behaviour, Nijmegen, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Zinnhardt, Bastian</creatorName>
      <givenName>Bastian</givenName>
      <familyName>Zinnhardt</familyName>
      <affiliation>European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms University Münster, Münster, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Reinhardt, Dirk</creatorName>
      <givenName>Dirk</givenName>
      <familyName>Reinhardt</familyName>
      <affiliation>European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms University Münster, Münster, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Eligehausen, Sarah</creatorName>
      <givenName>Sarah</givenName>
      <familyName>Eligehausen</familyName>
      <affiliation>European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms University Münster, Münster, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Wachsmuth, Lydia</creatorName>
      <givenName>Lydia</givenName>
      <familyName>Wachsmuth</familyName>
      <affiliation>Department of Clinical Radiology of the University Hospital, Westfälische Wilhelms University Münster, Münster, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Hermann, Sven</creatorName>
      <givenName>Sven</givenName>
      <familyName>Hermann</familyName>
      <affiliation>European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms University Münster, Münster, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Dederen, Pieter J</creatorName>
      <givenName>Pieter J</givenName>
      <familyName>Dederen</familyName>
      <affiliation>Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition &amp; Behaviour, Nijmegen, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Hellwich, Marloes</creatorName>
      <givenName>Marloes</givenName>
      <familyName>Hellwich</familyName>
      <affiliation>Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition &amp; Behaviour, Nijmegen, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Kuhlmann, Michael T</creatorName>
      <givenName>Michael T</givenName>
      <familyName>Kuhlmann</familyName>
      <affiliation>European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms University Münster, Münster, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Broersen, Laus</creatorName>
      <givenName>Laus</givenName>
      <familyName>Broersen</familyName>
      <affiliation>Advanced Medical Nutrition, Nutricia Research, Utrecht, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Heerschap, Arend</creatorName>
      <givenName>Arend</givenName>
      <familyName>Heerschap</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, Radboud university medical center, Nijmegen, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Jacobs, Andreas H</creatorName>
      <givenName>Andreas H</givenName>
      <familyName>Jacobs</familyName>
      <affiliation>European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms University Münster, Münster, Germany and Department of Geriatrics, Johanniter Hospital, Evangelische Kliniken, Bonn, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Kiliaan, Amanda J</creatorName>
      <givenName>Amanda J</givenName>
      <familyName>Kiliaan</familyName>
      <affiliation>Department of Anatomy, Radboud university medical center, Donders Institute for Brain, Cognition &amp; Behaviour, Nijmegen, The Netherlands</affiliation>
    </creator>
  </creators>
  <titles>
    <title>A specific dietary intervention to restore brain structure and function after ischemic stroke.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2017</publicationYear>
  <subjects>
    <subject>Cerebral Ischemia</subject>
    <subject>Neuroinflammation</subject>
    <subject>Cerebral Connectivity</subject>
    <subject>Cerebral Blood Flow</subject>
    <subject>MRI</subject>
    <subject>PET</subject>
    <subject>Animal Model</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2017-01-06</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/247065</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.7150/thno.17559</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic&lt;br&gt;
stroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core&lt;br&gt;
and an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable&lt;br&gt;
tissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in&lt;br&gt;
this cross-institutional study we investigated the neurorestorative efficacy of a dietary approach&lt;br&gt;
(Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline,&lt;br&gt;
phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to&lt;br&gt;
counteract neuroinflammation and impairments of cerebral (structural+functional) connectivity,&lt;br&gt;
cerebral blood flow (CBF), and motor function. Male adult C57BL/6j mice were subjected to right&lt;br&gt;
tMCAo using the intraluminal filament model. Following tMCAo, animals were either maintained&lt;br&gt;
on Control diet or switched to the multicomponent Fortasyn diet. At several time points after&lt;br&gt;
tMCAo, behavioral tests, and MRI and PET scanning were conducted to identify the impact of the&lt;br&gt;
multicomponent diet on the elicited neuroinflammatory response, loss of cerebral connectivity,&lt;br&gt;
and the resulting impairment of motor function after experimental stroke. Mice on the&lt;br&gt;
multicomponent diet showed decreased neuroinflammation, improved functional and structural&lt;br&gt;
connectivity, beneficial effect on CBF, and also improved motor function after tMCAo. Our&lt;br&gt;
present data show that this specific dietary intervention may have beneficial effects&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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