Journal article Open Access

A specific dietary intervention to restore brain structure and function after ischemic stroke.

Wiesmann, Maximilian; Zinnhardt, Bastian; Reinhardt, Dirk; Eligehausen, Sarah; Wachsmuth, Lydia; Hermann, Sven; Dederen, Pieter J; Hellwich, Marloes; Kuhlmann, Michael T; Broersen, Laus; Heerschap, Arend; Jacobs, Andreas H; Kiliaan, Amanda J

Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic
stroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core
and an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable
tissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in
this cross-institutional study we investigated the neurorestorative efficacy of a dietary approach
(Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline,
phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to
counteract neuroinflammation and impairments of cerebral (structural+functional) connectivity,
cerebral blood flow (CBF), and motor function. Male adult C57BL/6j mice were subjected to right
tMCAo using the intraluminal filament model. Following tMCAo, animals were either maintained
on Control diet or switched to the multicomponent Fortasyn diet. At several time points after
tMCAo, behavioral tests, and MRI and PET scanning were conducted to identify the impact of the
multicomponent diet on the elicited neuroinflammatory response, loss of cerebral connectivity,
and the resulting impairment of motor function after experimental stroke. Mice on the
multicomponent diet showed decreased neuroinflammation, improved functional and structural
connectivity, beneficial effect on CBF, and also improved motor function after tMCAo. Our
present data show that this specific dietary intervention may have beneficial effects

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