Journal article Open Access
Lakshmi Radhika K*, Dineshkumar B, K. Krishnakumar*
One of the most important ways for non-invasive delivery of drugs is human skin. But some high molecular weight (> 500 Dalton) compounds can’t cross the skin. Such type of compounds require some novel techniques. Vesicular systems like liposomes, niosomes, proniosomes are mainly used for this purpose, they have the ability to transfer the high molecular weight compounds across the skin. This article mainly describes the significance of Proniosomes. Proniosomes are the water-soluble carrier particles covered with a nonionic surfactant. It has the potential advantages over liposomes and niosomes. The Proniosomal gel is one of the new vesicular system used for transdermal drug delivery. Proniosomal gel is a semisolid crystalline product of nonionic surfactant. This review provides an overview of preparation, formulation, evaluation of proniosomes and which are the herbal drugs formulated as a proniosomal gel.