10.5281/zenodo.2384511
https://zenodo.org/records/2384511
oai:zenodo.org:2384511
R. Santosh Kumar, Abhishiktha Godthi
Abhishiktha Godthi
R. Santosh Kumar
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam-45.
FLOATING MULTIPARTICULATE SYSTEMS: A NOVEL APPROACH IN GASTRORETENTIVE DRUG DELIVERY SYSTEMS
Zenodo
2017
Floating, Multiparticulate Systems, Microspheres, Beads, Granules.
2017-03-31
10.5281/zenodo.2384510
https://zenodo.org/communities/iajpr
Creative Commons Attribution 4.0 International
Recent advances in novel drug delivery system to enhance the safety and efficacy of the drug molecule by formulating a dosage form being convenient for administration. A controlled drug delivery system with prolonged residence time in the stomach can be of great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastro-intestinal (GI) transit time and the non-uniformity of drug absorption throughout the alimentary canal. Floating drug delivery systems (FDDSs) are expected to remain buoyant in a lasting way upon the gastric contents and consequently to enhance the bioavailability of drugs. The various buoyant preparations include hollow microspheres, granules, beads and powders. Multiparticulate low-density particles can successfully prolong the gastric retention time of drugs. This article is a review of important approaches utilized in the preparation of floating multiparticulate systems, characterization of floating multiparticulate systems and recent research work done on floating multiparticulate systems.