Journal article Open Access

FLOATING MULTIPARTICULATE SYSTEMS: A NOVEL APPROACH IN GASTRORETENTIVE DRUG DELIVERY SYSTEMS

R. Santosh Kumar, Abhishiktha Godthi

Recent advances in novel drug delivery system to enhance the safety and efficacy of the drug molecule by formulating a dosage form being convenient for administration. A controlled drug delivery system with prolonged residence time in the stomach can be of great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastro-intestinal (GI) transit time and the non-uniformity of drug absorption throughout the alimentary canal. Floating drug delivery systems (FDDSs) are expected to remain buoyant in a lasting way upon the gastric contents and consequently to enhance the bioavailability of drugs. The various buoyant preparations include hollow microspheres, granules, beads and powders. Multiparticulate low-density particles can successfully prolong the gastric retention time of drugs. This article is a review of important approaches utilized in the preparation of floating multiparticulate systems, characterization of floating multiparticulate systems and recent research work done on floating multiparticulate systems.

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