Journal article Open Access
Varsha K.P*, K Krishnakumar, Dineshkumar B*
Natural polyphenolic compounds have several health benefits and no side effects compared to synthetic compounds. But these compounds having low water solubility, poor bioavailability, lack in long-term stability and are very sensitive to light. These compounds via nano-sized colloidal carriers such as polymeric nanoparticles offers a novel strategy to overcome these limitations. Nano-encapsulation remains to be the one of the most promising technologies having the ability to entrap polyphenolic compounds. These nano-encapsulated compounds has versatile advantages for targeted site-specific delivery and efficient absorption through cells. This review presents about main classes of polyphenolic compounds, their advantages, polymers used in the preparation of nanoparticles and the various techniques to create nanoparticles encapsulating polyphenols that will increase their solubility and bioavailability.