{ "access": { "embargo": { "active": false, "reason": null }, "files": "public", "record": "public", "status": "open" }, "created": "2018-12-18T09:12:09.285630+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "files": { "count": 1, "enabled": true, "entries": { "15.pdf": { "checksum": "md5:5bbb4693bcbdaa03e82ea6b4d803f2a7", "ext": "pdf", "id": "7eab82d0-21d9-457d-a5c4-11e8f5024f80", "key": "15.pdf", "metadata": null, "mimetype": "application/pdf", "size": 596300 } }, "order": [], "total_bytes": 596300 }, "id": "2383507", "is_draft": false, "is_published": true, "links": { "access": "https://zenodo.org/api/records/2383507/access", "access_links": "https://zenodo.org/api/records/2383507/access/links", "access_request": "https://zenodo.org/api/records/2383507/access/request", "access_users": "https://zenodo.org/api/records/2383507/access/users", "archive": "https://zenodo.org/api/records/2383507/files-archive", "archive_media": "https://zenodo.org/api/records/2383507/media-files-archive", "communities": "https://zenodo.org/api/records/2383507/communities", "communities-suggestions": "https://zenodo.org/api/records/2383507/communities-suggestions", "doi": "https://doi.org/10.5281/zenodo.2383507", "draft": "https://zenodo.org/api/records/2383507/draft", "files": "https://zenodo.org/api/records/2383507/files", "latest": "https://zenodo.org/api/records/2383507/versions/latest", "latest_html": "https://zenodo.org/records/2383507/latest", "media_files": "https://zenodo.org/api/records/2383507/media-files", "parent": "https://zenodo.org/api/records/2383506", "parent_doi": "https://zenodo.org/doi/10.5281/zenodo.2383506", "parent_html": "https://zenodo.org/records/2383506", "requests": "https://zenodo.org/api/records/2383507/requests", "reserve_doi": "https://zenodo.org/api/records/2383507/draft/pids/doi", "self": "https://zenodo.org/api/records/2383507", "self_doi": "https://zenodo.org/doi/10.5281/zenodo.2383507", "self_html": "https://zenodo.org/records/2383507", "self_iiif_manifest": "https://zenodo.org/api/iiif/record:2383507/manifest", "self_iiif_sequence": "https://zenodo.org/api/iiif/record:2383507/sequence/default", "versions": "https://zenodo.org/api/records/2383507/versions" }, "media_files": { "count": 0, "enabled": false, "entries": {}, "order": [], "total_bytes": 0 }, "metadata": { "creators": [ { "affiliations": [ { "name": "1Sri Venkateswara College of Pharmacy, Etcherla, Srikakulam, Andhra Pradesh, INDIA-532410 2AU. College of Pharmaceutical Sciences, Andhra University, Visakha Patnam." } ], "person_or_org": { "family_name": "Ch. Taraka Ramarao*1, B. Srinivasa Rao2, Prof. J. Vijaya ratna2", "name": "Ch. Taraka Ramarao*1, B. Srinivasa Rao2, Prof. J. Vijaya ratna2", "type": "personal" } } ], "description": "
The Matrix Tablets each containing 50 mg of diclofenac sodium are prepared
\nemploying kollidonSR by direct compression method. The hardness of the tablets was
\nin the range of 6-7kg/sq.cm. Weight loss in friability test was less than 0.3% in all the
\ncases. All the matrix tablets prepared contained 100 ± 2.3% of the labelled claim. All
\nthe tablets were found to be non-disintegrating in acidic (pH1.2) and alkaline (pH 7.4)
\nfluids. As such, the prepared tablets were of good quality with respect to drug content,
\nhardness and friability. As the tablets formulated were non- disintegrating in acidic
\nand alkaline fluids, they are considered suitable for colon targeting. From the drug
\nrelease study it may be concluded that the (DK2) P2 formula of diclofenac sodium
\nmatrix tablets have given the desired release profile by showing a minimal release
\nduring the lag period of 5 hrs and complete release at the end of 12 hrs. The tablets
\nhaving the optimised formula (DK2) P2, having 25% kollidonSR with 5% of
\nchannelling agent (PEG 6000) showed minimal release of 46% in the lag period of 5
\nhours and 99.6 % of the drug was released y the end of 12hours. The diclofenac
\nsodium matrix tablets formulated by employing kollidonSR and channelling agent
\nshowed non-fickian diffusion mechanism and following zero order kinetics. The
\noptimized formula (DK2) P2 follows Supercase II transport as mechanism for drug
\nrelease and it follows zero order kinetics. Matrix tablets (DK2) P2 formulated
\nemploying 25% kollidonSR and 5% PEG 6000 are best suited to be used for colon
\ntargeting of diclofenac sodium.
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", "title": "INDO AMERICAN JOURNAL OF PHARAMACEUTICAL RESEARCH" }, "revision_id": 0, "slug": "iajpr", "updated": "2018-12-12T10:30:14.233873+00:00" } ], "ids": [ "771e8d7c-d985-41ac-8e4e-6c99aad567fc" ] }, "id": "2383506", "pids": { "doi": { "client": "datacite", "identifier": "10.5281/zenodo.2383506", "provider": "datacite" } } }, "pids": { "doi": { "client": "datacite", "identifier": "10.5281/zenodo.2383507", "provider": "datacite" }, "oai": { "identifier": "oai:zenodo.org:2383507", "provider": "oai" } }, "revision_id": 4, "stats": { "all_versions": { "data_volume": 47704000.0, "downloads": 80, "unique_downloads": 77, "unique_views": 149, "views": 150 }, "this_version": { "data_volume": 47704000.0, "downloads": 80, "unique_downloads": 77, "unique_views": 149, "views": 150 } }, "status": "published", "updated": "2020-01-20T17:08:43.106309+00:00", "versions": { "index": 1, "is_latest": true } }