Journal article Open Access


Aroosa Siddique*, Madiha Jabeen, Osman Ahmed

Amentoflavone, is a bioflavonoid constituent of some of flora which includes ginkgo biloba, hypericum perforatum. It can have interaction with many medicinal drugs by using being a potent inhibitor of CYP3A4 and CYP2C9 which are enzymes chargeable for the metabolism of some drugs in the body. Flavonoids exhibit a extensive variety of activities including antioxidant, antiviral, Antibacterial and anticancer pastime. As formerly we showed that amentoflavone is an activator of hPPARγ. Human PPARγ (hPPARγ) regulates the proliferation, apoptosis, and various human most cancers cells. Activated hPPARγ has both tumor suppressor and tumor promoter. To affirm the mechanism of motion of amentoflavone in most cancers cells, we analyzed whether or not amentoflavone remedy affects the appearance of hPPARy the use of opposite transcription polymerase chain response and actual time quantitive PCR. Amentoflavone is synthesized with the aid of way of three techniques i.e natural, semi synthetic and synthetic methods. Among this synthetic method is widely used industrially. Application of the Suzuki-Miyaura response within the synthesis of flavonoids, is of vital magnificence of natural merchandise, is studied. Amentoflavone and three different flavonoids were separated from the ethanol extract of Selaginella sinensis. Amentoflavone show strong antiviral pastime in opposition to respiratory syncytial virus (RSV). The cytotoxic interest of amentoflavone is examined against 5 human most cancers cell strains (MCF-7, A549, HeLa, MDA-MB231, and PC3) treating with tetrazolium-primarily based colorimetric MTT assay. There is not such decided fixed dosage of amentoflavone.

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