2381685
doi
10.5281/zenodo.2381685
oai:zenodo.org:2381685
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3-BENZAZEPINONE DERIVATIVES: ANTIOXIDANT ACTIVITY AND ITS STRUCTURE ACTIVITY RELATIONSHIP (SAR) STUDIES
T. Shubhavathi1, Raghu Ram Achar2, B.S. Priya1*
1DOS in Chemistry, University of Mysore, Manasagangotri, Mysuru-570 006, Karnataka, India. 2Department of Biotechnology, JSS Science and Technology University, JSS Technical Institutions Campus, Mysuru, 570 006, Karnataka, India.
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Creative Commons Attribution 4.0 International
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3-Benzazepinones, Antioxidant Activity, Electron donating moieties, Structure Activity Relationship.
<p>A series of 3-benzazepinone (3-BZ) derivatives were tested for their in vitro antioxidant efficacy by DPPH and LPO assays and compared with standard Butylated Hydroxyl Anisole (BHA). The derivatives containing electron donating groups viz., OH, OCH3 were found to be good antioxidants compared to BHA. While, the compounds containing electron withdrawing moiety viz., NO2, Cl, Br, and F were found to be less active compared to standard BHA. The structure activity relationship studies suggest that the electron donating moieties majorly contribute to the anti-oxidant property of the potent compounds. Furthermore, analogs and more variants of the potent molecules can be synthesized to test for better antioxidants with lesser IC50 values.</p>
Zenodo
2017-01-31
info:eu-repo/semantics/article
2381684
user-iajpr
1579542325.757282
711514
md5:8a69ed5cbeb1b9c799cd8dd5c69684bf
https://zenodo.org/records/2381685/files/22.pdf
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10.5281/zenodo.2381684
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doi