Journal article Open Access
T. Shubhavathi1, Raghu Ram Achar2, B.S. Priya1*
A series of 3-benzazepinone (3-BZ) derivatives were tested for their in vitro antioxidant efficacy by DPPH and LPO assays and compared with standard Butylated Hydroxyl Anisole (BHA). The derivatives containing electron donating groups viz., OH, OCH3 were found to be good antioxidants compared to BHA. While, the compounds containing electron withdrawing moiety viz., NO2, Cl, Br, and F were found to be less active compared to standard BHA. The structure activity relationship studies suggest that the electron donating moieties majorly contribute to the anti-oxidant property of the potent compounds. Furthermore, analogs and more variants of the potent molecules can be synthesized to test for better antioxidants with lesser IC50 values.