Journal article Open Access

3-BENZAZEPINONE DERIVATIVES: ANTIOXIDANT ACTIVITY AND ITS STRUCTURE ACTIVITY RELATIONSHIP (SAR) STUDIES

T. Shubhavathi1, Raghu Ram Achar2, B.S. Priya1*

A series of 3-benzazepinone (3-BZ) derivatives were tested for their in vitro antioxidant efficacy by DPPH and LPO assays and compared with standard Butylated Hydroxyl Anisole (BHA). The derivatives containing electron donating groups viz., OH, OCH3 were found to be good antioxidants compared to BHA. While, the compounds containing electron withdrawing moiety viz., NO2, Cl, Br, and F were found to be less active compared to standard BHA. The structure activity relationship studies suggest that the electron donating moieties majorly contribute to the anti-oxidant property of the potent compounds. Furthermore, analogs and more variants of the potent molecules can be synthesized to test for better antioxidants with lesser IC50 values.

Files (711.5 kB)
Name Size
22.pdf
md5:8a69ed5cbeb1b9c799cd8dd5c69684bf
711.5 kB Download
18
10
views
downloads
All versions This version
Views 1818
Downloads 1010
Data volume 7.1 MB7.1 MB
Unique views 1818
Unique downloads 1010

Share

Cite as